What the FDA labels say about taking them together
Canagliflozin and digoxin
Canagliflozin's FDA label of June 11, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name canagliflozin. The canagliflozin label: “Canagliflozin increases digoxin exposure.”
Check it at the source: the canagliflozin FDA label on DailyMed (effective June 11, 2026, Janssen Pharmaceuticals, Inc.); the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the canagliflozin label say about digoxin?
Canagliflozin label, drug interactionsDigoxin Clinical Impact: Canagliflozin increases digoxin exposure. Intervention: Monitor patients taking INVOKANA with concomitant digoxin for a need to adjust the dosage of digoxin.
Source: FDA drug label (INVOKANA), Janssen Pharmaceuticals, Inc., effective June 11, 2026 (SPL set b9057d3b-b104-4f09-8a61-c61ef9d4a3f3), via openFDA; the full label on DailyMed
What does the digoxin label say about canagliflozin?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name canagliflozin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Canagliflozin | Digoxin | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, Type 2 diabetes, Chronic kidney disease | Heart failure, Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $19.13 per tablet 100 mg tablet | $0.133 per tablet 125 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once