Canagliflozin and Lithium Interaction
Drug interaction information between Canagliflozin and Lithium.
Canagliflozin and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Canagliflozin and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Canagliflozin can cause the body to remove lithium more quickly, which lowers the amount of lithium in your blood.
FDA Label Information
Lithium Clinical Impact: Concomitant use of an SGLT2 inhibitor with lithium may decrease serum lithium concentrations. Intervention: Monitor serum lithium concentration more frequently during INVOKANA initiation and dosage changes.
Canagliflozin Also Interacts With
- Rifampin moderate
- Phenytoin moderate
- Phenobarbital moderate
- Digoxin minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Canagliflozin + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Canagliflozin's 5. In the minor band specifically: Canagliflozin has 2 (also Digoxin); Lithium has 65 (also Aripiprazole, Asenapine, Candesartan, Celecoxib).
What mechanism field is on file for Canagliflozin and Lithium?
Canagliflozin can cause the body to remove lithium more quickly, which lowers the amount of lithium in your blood.
Lithium carries more major-labeled pairs than Canagliflozin
SPL source-record counts only. This page's band is minor · classes on file: Canagliflozin (SGLT2 Inhibitor); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Canagliflozin's 0. This page itself is in the minor band, not the major band.
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Candesartan
- Celecoxib
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.