What the FDA labels say about taking them together
Canagliflozin and lithium
Canagliflozin's FDA label of June 11, 2026 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name canagliflozin. The canagliflozin label: “Concomitant use of an SGLT2 inhibitor with lithium may decrease serum lithium concentrations.”
Check it at the source: the canagliflozin FDA label on DailyMed (effective June 11, 2026, Janssen Pharmaceuticals, Inc.); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the canagliflozin label say about lithium?
Canagliflozin label, drug interactionsClinical Impact: Concomitant use of an SGLT2 inhibitor with lithium may decrease serum lithium concentrations. Intervention: Monitor serum lithium concentration more frequently during INVOKANA initiation and dosage changes. Drug/Laboratory Test Interference Positive Urine Glucose Test
Source: FDA drug label (INVOKANA), Janssen Pharmaceuticals, Inc., effective June 11, 2026 (SPL set b9057d3b-b104-4f09-8a61-c61ef9d4a3f3), via openFDA; the full label on DailyMed
What does the lithium label say about canagliflozin?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name canagliflozin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Canagliflozin | Lithium | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, Type 2 diabetes, Chronic kidney disease | Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $19.13 per tablet 100 mg tablet | $0.104 per capsule 300 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once