Canagliflozin and Lithium Interaction
Drug interaction information between Canagliflozin and Lithium.
Canagliflozin and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Canagliflozin and Lithium. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Canagliflozin can cause the body to remove lithium more quickly, which lowers the amount of lithium in your blood.
What To Do
Your doctor should check your lithium blood levels more often when you start or change your dose of canagliflozin.
FDA Label Information
Lithium Clinical Impact: Concomitant use of an SGLT2 inhibitor with lithium may decrease serum lithium concentrations. Intervention: Monitor serum lithium concentration more frequently during INVOKANA initiation and dosage changes.
Canagliflozin Also Interacts With
- Rifampin moderate
- Phenytoin moderate
- Phenobarbital moderate
- Digoxin minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
Can I take Canagliflozin and Lithium together?
This is a minor interaction. Your doctor should check your lithium blood levels more often when you start or change your dose of canagliflozin.
How serious is the interaction between Canagliflozin and Lithium?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Canagliflozin and Lithium interact?
Canagliflozin can cause the body to remove lithium more quickly, which lowers the amount of lithium in your blood.
Understanding the Canagliflozin and Lithium Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Canagliflozin belongs to the SGLT2 Inhibitor class and Lithium belongs to the Mood Stabilizer class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Canagliflozin can cause the body to remove lithium more quickly, which lowers the amount of lithium in your blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Canagliflozin has 5 total documented interactions on file in this dataset, and Lithium has 90. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should check your lithium blood levels more often when you start or change your dose of canagliflozin. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Canagliflozin or Lithium based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.