Canagliflozin and Phenytoin Interaction
Drug interaction information between Canagliflozin and Phenytoin.
Canagliflozin and Phenytoin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Canagliflozin and Phenytoin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Phenytoin can cause your body to process canagliflozin more quickly, which may lower the amount of medicine in your system.
FDA Label Information
Examples: Rifampin, phenytoin, phenobarbital, ritonavir Insulin or Insulin Secretagogues Clinical Impact: The risk of hypoglycemia is increased when INVOKANA is used concomitantly with insulin secretagogues (e.g., sulfonylurea) or insulin.
Canagliflozin Also Interacts With
- Rifampin moderate
- Phenobarbital moderate
- Lithium minor
- Digoxin minor
Phenytoin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Posaconazole major
- Ranolazine major
- Voriconazole major
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Canagliflozin + Phenytoin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenytoin has 147 labeled pairs on file vs Canagliflozin's 5. In the moderate band specifically: Canagliflozin has 3 (also Rifampin, Phenobarbital); Phenytoin has 23 (also Apixaban, Aprepitant, Carbidopa/Levodopa, Clarithromycin).
What mechanism field is on file for Canagliflozin and Phenytoin?
Phenytoin can cause your body to process canagliflozin more quickly, which may lower the amount of medicine in your system.
Phenytoin carries more major-labeled pairs than Canagliflozin
SPL source-record counts only. This page's band is moderate · classes on file: Canagliflozin (SGLT2 Inhibitor); Phenytoin (Anticonvulsant (Hydantoin)).
Phenytoin has 4 major-labeled pairs vs Canagliflozin's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 2 minor · 5 total
- Other moderate peers for Canagliflozin
- Rifampin
- Phenobarbital
4 major · 23 moderate · 120 minor · 147 total
- Other moderate peers for Phenytoin
- Apixaban
- Aprepitant
- Carbidopa/Levodopa
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.