What the FDA labels say about taking them together
Canagliflozin and phenytoin
Canagliflozin's FDA label of June 11, 2026 names phenytoin in its drug interactions section; the phenytoin labels PlainMeds reads (2) do not name canagliflozin. The canagliflozin label: “UGT enzyme inducers decrease canagliflozin exposure which may reduce the effectiveness of INVOKANA.”
Check it at the source: the canagliflozin FDA label on DailyMed (effective June 11, 2026, Janssen Pharmaceuticals, Inc.); the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.).
What does the canagliflozin label say about phenytoin?
Canagliflozin label, drug interactionsUGT Enzyme Inducers Clinical Impact: UGT enzyme inducers decrease canagliflozin exposure which may reduce the effectiveness of INVOKANA. … antihyperglycemic agent in patients who require additional glycemic control [see and ]. Examples: Rifampin, phenytoin, phenobarbital, ritonavir
Source: FDA drug label (INVOKANA), Janssen Pharmaceuticals, Inc., effective June 11, 2026 (SPL set b9057d3b-b104-4f09-8a61-c61ef9d4a3f3), via openFDA; the full label on DailyMed
What does the phenytoin label say about canagliflozin?
Phenytoin's label (effective October 15, 2024) and its 1 other brand-application label do not name canagliflozin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Canagliflozin | Phenytoin | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, Type 2 diabetes, Chronic kidney disease | Seizures and epilepsy |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $19.13 per tablet 100 mg tablet | $0.145 per capsule 100 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once