Canagliflozin and Rifampin Interaction
Drug interaction information between Canagliflozin and Rifampin.
Canagliflozin and Rifampin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Canagliflozin and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin causes your body to process and remove the diabetes medicine more quickly than usual. This can make the diabetes medicine less effective at lowering your blood sugar.
FDA Label Information
Examples: Rifampin, phenytoin, phenobarbital, ritonavir Insulin or Insulin Secretagogues Clinical Impact: The risk of hypoglycemia is increased when INVOKANA is used concomitantly with insulin secretagogues (e.g., sulfonylurea) or insulin.
Canagliflozin Also Interacts With
- Phenytoin moderate
- Phenobarbital moderate
- Lithium minor
- Digoxin minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Canagliflozin + Rifampin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Canagliflozin's 5. In the moderate band specifically: Canagliflozin has 3 (also Phenytoin, Phenobarbital); Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban).
What mechanism field is on file for Canagliflozin and Rifampin?
Rifampin causes your body to process and remove the diabetes medicine more quickly than usual. This can make the diabetes medicine less effective at lowering your blood sugar.
Rifampin carries more major-labeled pairs than Canagliflozin
SPL source-record counts only. This page's band is moderate · classes on file: Canagliflozin (SGLT2 Inhibitor); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Canagliflozin's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 2 minor · 5 total
- Other moderate peers for Canagliflozin
- Phenytoin
- Phenobarbital
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.