Bupropion · more major-labeled pairs than Clozapine

SPL labels Bupropion + Clozapine as minor; Bupropion 32 / Clozapine 39 in that band.

Mechanism on file: Bupropion blocks the proteins in your body that break down clozapine, which can cause clozapine to build up in your blood.

FDA SPL severity: Minor

Bupropion

Full Bupropion label record

Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)

Clozapine

Full Clozapine label record

Atypical Antipsychotic

Bupropion + Clozapine · SPL mechanism field

Bupropion blocks the proteins in your body that break down clozapine, which can cause clozapine to build up in your blood.

Minor band excerpt · Bupropion with Clozapine

CYP2D6 and CYP3A4 Inhibitors Concomitant treatment with VERSACLOZ and CYP2D6 or CYP3A4 inhibitors (e.g., cimetidine, escitalopram, erythromycin, paroxetine, bupropion, fluoxetine, quinidine, duloxetine, terbinafine, or sertraline) can increase clozapine levels and lead to adverse reactions [see Clinical Pharmacology (12.3) ] .

Bupropion · 1 major-labeled pairs (vs Clozapine's 0)

View all Bupropion interactions →

Clozapine · 42 SPL pairs (broader portfolio than Bupropion)

View all Clozapine interactions →

FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.