Bupropion · more major-labeled pairs than Codeine
SPL labels Bupropion + Codeine as minor; Bupropion 32 / Codeine 27 in that band.
Mechanism on file: Bupropion blocks the body from changing codeine into morphine, which is the active part that relieves pain. This can make the medicine less effective or cause withdrawal symptoms.
FDA SPL severity: Minor
Bupropion + Codeine · SPL mechanism field
Bupropion blocks the body from changing codeine into morphine, which is the active part that relieves pain. This can make the medicine less effective or cause withdrawal symptoms.
Minor band excerpt · Bupropion with Codeine
The concomitant use of acetaminophen and codeine phosphate tablets and CYP2D6 inhibitors (e.g., paroxetine, fluoxetine, bupropion, quinidine) can increase the plasma concentration of codeine, but can decrease the plasma concentration of active metabolite morphine, which could result in reduced analgesic efficacy or symptoms of opioid withdrawal, particularly when an inhibitor is added after a stable dose of acetaminophen and codeine phosphate tablets is achieved (see CLINICAL PHARMACOLOGY ).
Bupropion · 1 major-labeled pairs (vs Codeine's 0)
- Brexpiprazole minor
- Carbamazepine minor
- Clopidogrel minor
- Clozapine minor
Codeine · 27 minor + 27 total pairs
- Acetaminophen minor
- Alprazolam minor
- Buprenorphine minor
- Butorphanol minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.