Clozapine · larger labeled portfolio than Chlorpromazine
SPL labels Clozapine + Chlorpromazine as minor; Clozapine 39 / Chlorpromazine 7 in that band.
Mechanism on file: These two drugs both affect the heart's electrical system in the same way. Using them at the same time can lead to serious heart rhythm problems.
FDA SPL severity: Minor
Clozapine + Chlorpromazine · SPL mechanism field
These two drugs both affect the heart's electrical system in the same way. Using them at the same time can lead to serious heart rhythm problems.
Minor band excerpt · Clozapine with Chlorpromazine
Drugs that cause QT prolongation include: specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, thioridazine, mesoridazine, droperidol, and pimozide), specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin), Class 1A antiarrhythmics (e.g., quinidine, procainamide) or Class III antiarrhythmics (e.g., amiodarone, sotalol), and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus) [see Warnings and Precautions (5.9) ] .
Clozapine · 42 SPL pairs (broader portfolio than Chlorpromazine)
- Amiodarone minor
- Bupropion minor
- Carbamazepine minor
- Cimetidine minor
Chlorpromazine · 7 minor + 11 total pairs
- Carbamazepine minor
- Fluoxetine minor
- Meperidine minor
- Pimozide minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.