Cimetidine · more major-labeled pairs than Clozapine
SPL labels Clozapine + Cimetidine as minor; Clozapine 39 / Cimetidine 63 in that band.
Mechanism on file: Cimetidine blocks the liver enzymes that normally clear clozapine from your body. This causes clozapine levels to rise, which can lead to more side effects.
FDA SPL severity: Minor
Clozapine + Cimetidine · SPL mechanism field
Cimetidine blocks the liver enzymes that normally clear clozapine from your body. This causes clozapine levels to rise, which can lead to more side effects.
Minor band excerpt · Clozapine with Cimetidine
CYP2D6 and CYP3A4 Inhibitors Concomitant treatment with VERSACLOZ and CYP2D6 or CYP3A4 inhibitors (e.g., cimetidine, escitalopram, erythromycin, paroxetine, bupropion, fluoxetine, quinidine, duloxetine, terbinafine, or sertraline) can increase clozapine levels and lead to adverse reactions [see Clinical Pharmacology (12.3) ] .
Clozapine · 39 minor + 42 total pairs
- Amiodarone minor
- Bupropion minor
- Carbamazepine minor
- Chlorpromazine minor
Cimetidine · 4 major-labeled pairs (vs Clozapine's 0)
- Albendazole minor
- Alogliptin minor
- Alosetron minor
- Alprazolam minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.