bupropion vs clozapine
Side-by-side comparison of bupropion and clozapine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
CYP2D6 and CYP3A4 Inhibitors Concomitant treatment with VERSACLOZ and CYP2D6 or CYP3A4 inhibitors (e.g., cimetidine, escitalopram, erythromycin, paroxetine, bupropion, fluoxetine, quinidine, duloxetine, terbinafine, or sertraline) can increase clozapine levels and lead to adverse reactions [see Clinical Pharmacology (12.3) ] .
Recommendation: Your doctor may need to adjust your clozapine dose or watch you more closely for side effects while taking these together.
Bupropion is a medicine used to treat depression and prevent seasonal affective disorder (SAD). It can help improve your mood and energy levels.
Versacloz is a medicine used to treat severe schizophrenia when other medicines have not worked. It can also help lower the risk of suicidal behavior in people with schizophrenia or schizoaffective disorder.
Bupropion is used to treat major depressive disorder (MDD), which can cause you to feel sad, lose interest in activities, and have trouble sleeping or eating. It is also used to prevent seasonal affective disorder (SAD), a type of depression that occurs during the fall and winter.
Versacloz is used to treat schizophrenia in people who haven't responded well to other antipsychotic medicines. Schizophrenia is a mental illness that can cause hallucinations, delusions, and disorganized thinking. Versacloz can also help lower the risk of repeated suicidal behavior in people with schizophrenia or schizoaffective disorder who are at high risk.
Bupropion works by affecting certain chemicals in the brain called norepinephrine and dopamine. It helps to increase the levels of these chemicals, which can improve mood and reduce symptoms of depression.
Versacloz works by affecting certain chemicals in the brain. These chemicals, like dopamine and serotonin, are involved in mood, behavior, and thinking. By changing the levels of these chemicals, Versacloz can help reduce symptoms of schizophrenia and lower the risk of suicidal behavior.
- • Dry mouth
- • Nausea
- • Trouble sleeping
- • Dizziness
- • Sore throat
- • Feeling sleepy
- • Dizziness
- • Headache
- • Shaking
- • Fast heart rate
- Suicide 4,408
- Poisoning 3,113
- Tiredness 2,665
- Feeling sick to your stomach 2,309
- Headache 2,218
- Low white blood cell count 18,655
- Needing to stay in the hospital 12,101
- Death 11,398
- A mental disorder that affects how a person thinks, feels, and behaves 4,547
- High white blood cell count 4,446
Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teenagers, and young adults. Watch closely for worsening depression or suicidal thoughts. Tell your doctor right away if you notice any changes in mood or behavior.
Versacloz can cause several serious side effects: * **Severe Neutropenia:** This means a dangerously low white blood cell count, which increases your risk of infection. You will need regular blood tests to check your white blood cell count. * **Orthostatic Hypotension, Bradycardia, and Syncope:** This means low blood pressure when standing up, slow heart rate, and fainting. These are most likely when you first start taking Versacloz or when the dose is increased. * **Seizures:** Versacloz can increase your risk of seizures, especially at higher doses. * **Myocarditis, Pericarditis, and Cardiomyopathy:** These are serious heart problems that can be fatal. Tell your doctor right away if you have chest pain, shortness of breath, or other heart-related symptoms. * **Increased Mortality in Elderly Patients with Dementia-Related Psychosis:** Elderly patients with dementia who take antipsychotic medicines like Versacloz have an increased risk of death.
Talk to your doctor if you are pregnant or plan to become pregnant. It is important to consider the risks of untreated depression during pregnancy. There is a pregnancy registry to monitor outcomes in women exposed to antidepressants during pregnancy. You can register by calling 1-844-405-6185.
Tell your doctor if you are pregnant or plan to become pregnant. Babies born to mothers who take Versacloz in the third trimester may have withdrawal symptoms or other problems after birth. There is a pregnancy registry for women who take atypical antipsychotics like Versacloz.
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How to Read This bupropion vs clozapine Comparison
bupropion is classified in the Norepinephrine-Dopamine Reuptake Inhibitor (NDRI) drug class, while clozapine sits within the Atypical Antipsychotic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, bupropion has 14,713 submissions while clozapine has 51,147. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to bupropion blocks the proteins in your body that break down clozapine, which can cause clozapine to build up in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between bupropion and clozapine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.