Amiodarone · more major-labeled pairs than Clozapine
SPL labels Clozapine + Amiodarone as minor; Clozapine 39 / Amiodarone 29 in that band.
Mechanism on file: Both of these drugs interfere with the electrical signals that control your heartbeat. Combining them significantly increases the risk of heart rhythm complications.
FDA SPL severity: Minor
Clozapine + Amiodarone · SPL mechanism field
Both of these drugs interfere with the electrical signals that control your heartbeat. Combining them significantly increases the risk of heart rhythm complications.
Minor band excerpt · Clozapine with Amiodarone
Drugs that cause QT prolongation include: specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, thioridazine, mesoridazine, droperidol, and pimozide), specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin), Class 1A antiarrhythmics (e.g., quinidine, procainamide) or Class III antiarrhythmics (e.g., amiodarone, sotalol), and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus) [see Warnings and Precautions (5.9) ] .
Clozapine · 39 minor + 42 total pairs
- Bupropion minor
- Carbamazepine minor
- Chlorpromazine minor
- Cimetidine minor
Amiodarone · 4 major-labeled pairs (vs Clozapine's 0)
- Atenolol minor
- Atorvastatin minor
- Carvedilol minor
- Cholestyramine minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.