What the FDA labels say about taking them together
Bempedoic acid and simvastatin
Bempedoic acid's FDA label of June 25, 2026 names simvastatin in its drug interactions section; the simvastatin label PlainMeds reads does not name bempedoic acid. The bempedoic acid label: “Concomitant use of NEXLETOL with simvastatin causes an increase in simvastatin concentration and may increase the risk of simvastatin-related myopathy.”
Check it at the source: the bempedoic acid FDA label on DailyMed (effective June 25, 2026, Esperion Therapeutics, Inc.); the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC).
What does the bempedoic acid label say about simvastatin?
Bempedoic acid label, drug interactionsSimvastatin Clinical Impact: Concomitant use of NEXLETOL with simvastatin causes an increase in simvastatin concentration and may increase the risk of simvastatin-related myopathy. Intervention: Avoid concomitant use of NEXLETOL with simvastatin greater than 20 mg.
Source: FDA drug label (Nexletol), Esperion Therapeutics, Inc., effective June 25, 2026 (SPL set 88d06d89-a3da-40b4-b273-8f4f7d56c4c9), via openFDA; the full label on DailyMed
What does the simvastatin label say about bempedoic acid?
Simvastatin's label (effective March 28, 2025) does not name bempedoic acid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Bempedoic acid | Simvastatin | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, High cholesterol | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $13.81 per tablet 180 mg tablet | $0.0321 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once