Phenobarbital and Canagliflozin Interaction
Drug interaction information between Phenobarbital and Canagliflozin.
Phenobarbital and Canagliflozin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Phenobarbital and Canagliflozin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Phenobarbital speeds up the breakdown of canagliflozin in your body, which can make the diabetes medicine less effective.
FDA Label Information
Examples: Rifampin, phenytoin, phenobarbital, ritonavir Insulin or Insulin Secretagogues Clinical Impact: The risk of hypoglycemia is increased when INVOKANA is used concomitantly with insulin secretagogues (e.g., sulfonylurea) or insulin.
Phenobarbital Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Voriconazole major
- Cenobamate moderate
- Clarithromycin moderate
Canagliflozin Also Interacts With
View all Canagliflozin interactions →Frequently Asked Questions
What SPL severity band is on file for Phenobarbital + Canagliflozin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenobarbital has 59 labeled pairs on file vs Canagliflozin's 5. In the moderate band specifically: Phenobarbital has 13 (also Cenobamate, Clarithromycin, Dapsone Topical, Dolutegravir/Lamivudine); Canagliflozin has 3 (also Rifampin, Phenytoin).
What mechanism field is on file for Phenobarbital and Canagliflozin?
Phenobarbital speeds up the breakdown of canagliflozin in your body, which can make the diabetes medicine less effective.
Phenobarbital carries more major-labeled pairs than Canagliflozin
SPL source-record counts only. This page's band is moderate · classes on file: Phenobarbital (Anticonvulsant (Barbiturate)); Canagliflozin (SGLT2 Inhibitor).
Phenobarbital has 3 major-labeled pairs vs Canagliflozin's 0. This page itself is in the moderate band, not the major band.
3 major · 13 moderate · 43 minor · 59 total
- Other moderate peers for Phenobarbital
- Cenobamate
- Clarithromycin
- Dapsone Topical
- Dolutegravir/Lamivudine
0 major · 3 moderate · 2 minor · 5 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.