Apixaban and Clarithromycin Interaction
Drug interaction information between Apixaban and Clarithromycin.
Apixaban and Clarithromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Apixaban and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin blocks the enzymes that break down apixaban, but the effect is not strong enough to require a change.
FDA Label Information
Clarithromycin Although clarithromycin is a combined P-gp and strong CYP3A4 inhibitor, pharmacokinetic data suggest that no dose adjustment is necessary with concomitant administration with apixaban [see Clinical Pharmacology ( 12.3) ].
Apixaban Also Interacts With
- Clopidogrel moderate
- Aspirin moderate
- Warfarin moderate
- Carbamazepine moderate
- Rifampin moderate
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Apixaban + Clarithromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Apixaban's 12. In the minor band specifically: Apixaban has 3 (also Ketoconazole, Itraconazole); Clarithromycin has 30 (also Amlodipine, Lorazepam, Diltiazem, Erythromycin).
What mechanism field is on file for Apixaban and Clarithromycin?
Clarithromycin blocks the enzymes that break down apixaban, but the effect is not strong enough to require a change.
Clarithromycin carries more major-labeled pairs than Apixaban
SPL source-record counts only. This page's band is minor · classes on file: Apixaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Apixaban's 0. This page itself is in the minor band, not the major band.
0 major · 9 moderate · 3 minor · 12 total
- Other minor peers for Apixaban
- Ketoconazole
- Itraconazole
16 major · 35 moderate · 30 minor · 81 total
- Other minor peers for Clarithromycin
- Amlodipine
- Lorazepam
- Diltiazem
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.