Apixaban and Warfarin Interaction
Drug interaction information between Apixaban and Warfarin.
Apixaban and Warfarin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Apixaban and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both medications are powerful blood thinners, and using them at the same time greatly increases the risk of dangerous bleeding. Combining these drugs makes it much more difficult for your body to stop any bleeding that starts.
FDA Label Information
In ARISTOTLE, concomitant use of aspirin increased the bleeding risk on apixaban from 1.8% per year to 3.4% per year and concomitant use of aspirin and warfarin increased the bleeding risk from 2.7% per year to 4.6% per year.
Apixaban Also Interacts With
- Clopidogrel moderate
- Aspirin moderate
- Carbamazepine moderate
- Rifampin moderate
- Heparin moderate
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Apixaban + Warfarin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Apixaban's 12. In the moderate band specifically: Apixaban has 9 (also Clopidogrel, Aspirin, Carbamazepine, Rifampin); Warfarin has 28 (also Ibuprofen, Aspirin, Diclofenac, Desvenlafaxine).
What mechanism field is on file for Apixaban and Warfarin?
Both medications are powerful blood thinners, and using them at the same time greatly increases the risk of dangerous bleeding. Combining these drugs makes it much more difficult for your body to stop any bleeding that starts.
Warfarin carries more major-labeled pairs than Apixaban
SPL source-record counts only. This page's band is moderate · classes on file: Apixaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Apixaban's 0. This page itself is in the moderate band, not the major band.
0 major · 9 moderate · 3 minor · 12 total
- Other moderate peers for Apixaban
- Clopidogrel
- Aspirin
- Carbamazepine
- Rifampin
2 major · 28 moderate · 133 minor · 163 total
- Other moderate peers for Warfarin
- Ibuprofen
- Aspirin
- Diclofenac
- Desvenlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.