Apixaban and Itraconazole Interaction
Drug interaction information between Apixaban and Itraconazole.
Apixaban and Itraconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Apixaban and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole blocks the enzymes and proteins that remove apixaban from your body, which can cause the drug to build up.
FDA Label Information
( 7.2 , 12.3 ) 7.1 Combined P-gp Strong CYP3A4 Inhibitors For patients receiving apixaban 5 mg or 10 mg twice daily, the dose of apixaban should be decreased by 50% when coadministered with drugs that are combined P-gp and strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir) [see Dosage and Administration (2.5) and Clinical Pharmacology ( 12.3) ].
Apixaban Also Interacts With
- Clopidogrel moderate
- Aspirin moderate
- Warfarin moderate
- Carbamazepine moderate
- Rifampin moderate
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Apixaban + Itraconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Apixaban's 12. In the minor band specifically: Apixaban has 3 (also Ketoconazole, Clarithromycin); Itraconazole has 77 (also Fluticasone, Meloxicam, Buspirone, Oxycodone).
What mechanism field is on file for Apixaban and Itraconazole?
Itraconazole blocks the enzymes and proteins that remove apixaban from your body, which can cause the drug to build up.
Itraconazole carries more major-labeled pairs than Apixaban
SPL source-record counts only. This page's band is minor · classes on file: Apixaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Apixaban's 0. This page itself is in the minor band, not the major band.
0 major · 9 moderate · 3 minor · 12 total
- Other minor peers for Apixaban
- Ketoconazole
- Clarithromycin
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Fluticasone
- Meloxicam
- Buspirone
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.