Amoxicillin/Clavulanate and Probenecid Interaction
Drug interaction information between Amoxicillin/Clavulanate and Probenecid.
Amoxicillin/Clavulanate and Probenecid have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Amoxicillin/Clavulanate and Probenecid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid slows down the kidneys from clearing amoxicillin out of your system, which can lead to higher levels of the drug in your body. It does not affect how the other part of the medicine, clavulanic acid, is removed.
FDA Label Information
7 DRUG INTERACTIONS Co‑administration with probenecid is not recommended. ( 7.4 ) 7.1 Probenecid Probenecid decreases the renal tubular secretion of amoxicillin but does not delay renal excretion of clavulanic acid. Co-administration of probenecid is not recommended.
Amoxicillin/Clavulanate Also Interacts With
- Allopurinol moderate
- Amoxicillin minor
- Estradiol minor
- Progesterone minor
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Ceftazidime/Avibactam moderate
- Cefuroxime moderate
Frequently Asked Questions
What SPL severity band is on file for Amoxicillin/Clavulanate + Probenecid?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Probenecid has 37 labeled pairs on file vs Amoxicillin/Clavulanate's 5. In the moderate band specifically: Amoxicillin/Clavulanate has 2 (also Allopurinol); Probenecid has 12 (also Amoxicillin, Ceftazidime/Avibactam, Cefuroxime, Cephalexin).
What mechanism field is on file for Amoxicillin/Clavulanate and Probenecid?
Probenecid slows down the kidneys from clearing amoxicillin out of your system, which can lead to higher levels of the drug in your body. It does not affect how the other part of the medicine, clavulanic acid, is removed.
Probenecid carries more major-labeled pairs than Amoxicillin/Clavulanate
SPL source-record counts only. This page's band is moderate · classes on file: Amoxicillin/Clavulanate (Penicillin / Beta-Lactamase Inhibitor Combination); Probenecid (Uricosuric Agent).
Probenecid has 2 major-labeled pairs vs Amoxicillin/Clavulanate's 0. This page itself is in the moderate band, not the major band.
0 major · 2 moderate · 3 minor · 5 total
- Other moderate peers for Amoxicillin/Clavulanate
- Allopurinol
2 major · 12 moderate · 23 minor · 37 total
- Other moderate peers for Probenecid
- Amoxicillin
- Ceftazidime/Avibactam
- Cefuroxime
- Cephalexin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.