Amoxicillin/Clavulanate and Amoxicillin Interaction
Drug interaction information between Amoxicillin/Clavulanate and Amoxicillin.
Amoxicillin/Clavulanate and Amoxicillin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amoxicillin/Clavulanate and Amoxicillin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This antibiotic can interfere with how your blood clots when it is taken with blood-thinning medications.
FDA Label Information
( 7.4 ) 7.1 Probenecid Probenecid decreases the renal tubular secretion of amoxicillin but does not delay renal excretion of clavulanic acid. Concurrent use with AUGMENTIN may result in increased and prolonged blood concentrations of amoxicillin. 7.2 Oral Anticoagulants Abnormal prolongation of prothrombin time (increased international normalized ratio [INR]) has been reported in patients receiving amoxicillin and oral anticoagulants.
Amoxicillin/Clavulanate Also Interacts With
- Allopurinol moderate
- Probenecid moderate
- Estradiol minor
- Progesterone minor
Amoxicillin Also Interacts With
- Lansoprazole major
- Rabeprazole major
- Theophylline major
- Allopurinol moderate
- Probenecid moderate
Frequently Asked Questions
What SPL severity band is on file for Amoxicillin/Clavulanate + Amoxicillin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amoxicillin has 12 labeled pairs on file vs Amoxicillin/Clavulanate's 5. In the minor band specifically: Amoxicillin/Clavulanate has 3 (also Estradiol, Progesterone); Amoxicillin has 7 (also Estradiol, Progesterone, Ethinyl Estradiol, Etonogestrel).
What mechanism field is on file for Amoxicillin/Clavulanate and Amoxicillin?
This antibiotic can interfere with how your blood clots when it is taken with blood-thinning medications.
Amoxicillin carries more major-labeled pairs than Amoxicillin/Clavulanate
SPL source-record counts only. This page's band is minor · classes on file: Amoxicillin/Clavulanate (Penicillin / Beta-Lactamase Inhibitor Combination); Amoxicillin (Penicillin Antibiotic).
Amoxicillin has 3 major-labeled pairs vs Amoxicillin/Clavulanate's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 3 minor · 5 total
- Other minor peers for Amoxicillin/Clavulanate
- Estradiol
- Progesterone
3 major · 2 moderate · 7 minor · 12 total
- Other minor peers for Amoxicillin
- Estradiol
- Progesterone
- Ethinyl Estradiol
- Etonogestrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.