Amoxicillin/Clavulanate and Estradiol Interaction
Drug interaction information between Amoxicillin/Clavulanate and Estradiol.
Amoxicillin/Clavulanate and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amoxicillin/Clavulanate and Estradiol. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
This medication can cause a temporary drop in the levels of estrogen hormones found in your blood.
What To Do
Consult your healthcare provider to see if you need to monitor your hormone levels or use additional birth control.
FDA Label Information
Following administration of amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted.
Amoxicillin/Clavulanate Also Interacts With
- Allopurinol moderate
- Probenecid moderate
- Amoxicillin minor
- Progesterone minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
Can I take Amoxicillin/Clavulanate and Estradiol together?
This is a minor interaction. Consult your healthcare provider to see if you need to monitor your hormone levels or use additional birth control.
How serious is the interaction between Amoxicillin/Clavulanate and Estradiol?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Amoxicillin/Clavulanate and Estradiol interact?
This medication can cause a temporary drop in the levels of estrogen hormones found in your blood.
Understanding the Amoxicillin/Clavulanate and Estradiol Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Amoxicillin/Clavulanate belongs to the Penicillin / Beta-Lactamase Inhibitor Combination class and Estradiol belongs to the Estrogen Hormone class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: This medication can cause a temporary drop in the levels of estrogen hormones found in your blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Amoxicillin/Clavulanate has 5 total documented interactions on file in this dataset, and Estradiol has 54. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Consult your healthcare provider to see if you need to monitor your hormone levels or use additional birth control. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Amoxicillin/Clavulanate or Estradiol based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.