Amoxicillin/Clavulanate and Estradiol Interaction
Drug interaction information between Amoxicillin/Clavulanate and Estradiol.
Amoxicillin/Clavulanate and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amoxicillin/Clavulanate and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medication can cause a temporary drop in the levels of estrogen hormones found in your blood.
FDA Label Information
Following administration of amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted.
Amoxicillin/Clavulanate Also Interacts With
- Allopurinol moderate
- Probenecid moderate
- Amoxicillin minor
- Progesterone minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Amoxicillin/Clavulanate + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Amoxicillin/Clavulanate's 5. In the minor band specifically: Amoxicillin/Clavulanate has 3 (also Amoxicillin, Progesterone); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Amoxicillin/Clavulanate and Estradiol?
This medication can cause a temporary drop in the levels of estrogen hormones found in your blood.
Estradiol carries more major-labeled pairs than Amoxicillin/Clavulanate
SPL source-record counts only. This page's band is minor · classes on file: Amoxicillin/Clavulanate (Penicillin / Beta-Lactamase Inhibitor Combination); Estradiol (Estrogen Hormone).
Estradiol has 1 major-labeled pair vs Amoxicillin/Clavulanate's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 3 minor · 5 total
- Other minor peers for Amoxicillin/Clavulanate
- Amoxicillin
- Progesterone
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.