What the FDA labels say about taking them together
Amoxicillin/clavulanate and estradiol
Amoxicillin/clavulanate's FDA label of May 1, 2025 names estradiol in its drug interactions section; the estradiol labels PlainMeds reads (4) do not name amoxicillin/clavulanate. The amoxicillin/clavulanate label: “Following administration of amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted.”
Check it at the source: the amoxicillin/clavulanate FDA label on DailyMed (effective May 1, 2025, Sandoz Inc); the estradiol FDA label on DailyMed (effective April 3, 2024, Amneal Pharmaceuticals LLC).
What does the amoxicillin/clavulanate label say about estradiol?
Amoxicillin/clavulanate label, drug interactionsFollowing administration of amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted.
Source: FDA drug label (Amoxicillin and Clavulanate Potassium), Sandoz Inc, effective May 1, 2025 (SPL set 7cba82f0-9886-46e9-8dbd-43a448aade29), via openFDA; the full label on DailyMed
What does the estradiol label say about amoxicillin/clavulanate?
Estradiol's label (effective April 3, 2024) and its 3 other brand-application labels do not name amoxicillin/clavulanate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (YUVAFEM), Amneal Pharmaceuticals LLC, effective April 3, 2024 (SPL set 30c7f6ba-7a9e-4853-b3e4-e00a46560224), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
These are the ingredient's own label sentences, repeated in a combination product's or a biosimilar's label. The ingredient pair sets them out with both labels side by side.
Both medicines on the record
| Amoxicillin/clavulanate | Estradiol | |
|---|---|---|
| Labeled for | Urinary tract infections, Bacterial infections | Menopause symptoms, Breast cancer, Osteoporosis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0693 per mL 600-42.9 mg/5 mL sus | $0.0635 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once