amoxicillin/clavulanate vs probenecid
Side-by-side comparison of amoxicillin/clavulanate and probenecid. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
7 DRUG INTERACTIONS Co‑administration with probenecid is not recommended. ( 7.4 ) 7.1 Probenecid Probenecid decreases the renal tubular secretion of amoxicillin but does not delay renal excretion of clavulanic acid. Co-administration of probenecid is not recommended.
Recommendation: This combination is not recommended by the manufacturer. Talk to your doctor about alternative treatments or necessary adjustments to your prescription.
Augmentin
Benemid
Augmentin is a combination of two medicines, amoxicillin and clavulanate. It is an antibiotic that fights bacteria in your body.
No summary available.
Augmentin treats infections caused by bacteria. It is used for infections such as lower respiratory infections, ear infections, sinus infections, skin infections, and urinary tract infections. This medicine will not work for viral infections, such as colds or the flu.
Information not available.
Amoxicillin kills bacteria. Clavulanate helps amoxicillin work better by preventing bacteria from breaking down amoxicillin. This combination helps to fight a wider range of bacteria.
Information not available.
- • Diarrhea or loose stools
- • Nausea
- • Skin rashes
- • Hives
- • Vomiting
- • Diarrhea
- • Nausea
- • Yeast infection of the vagina
- • Headache
- • Vomiting
- Long-term kidney disease 4,661
- Sudden kidney damage 4,200
- Diarrhea 4,083
- Drug allergy 3,744
- Feeling sick to your stomach 3,700
- Diarrhea 76
- Difficulty breathing 52
- Adenovirus infection 47
- Weakness 47
- Tiredness 46
Augmentin can cause serious allergic reactions, including fatal ones. Stop taking Augmentin and get medical help right away if you have any signs of an allergic reaction. Augmentin can also cause severe skin reactions. Tell your doctor if you develop a rash. This drug can also cause liver problems and severe diarrhea.
No specific warnings noted.
Animal studies show Augmentin may be safe during pregnancy, but there are no good studies in pregnant women. Talk to your doctor if you are pregnant or plan to become pregnant. Amoxicillin passes into breast milk and may cause problems for the baby, so talk to your doctor if you are breastfeeding.
No pregnancy information available.
How to Read This amoxicillin/clavulanate vs probenecid Comparison
amoxicillin/clavulanate is classified in the Penicillin / Beta-Lactamase Inhibitor Combination drug class, while probenecid sits within the Uricosuric Agent class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, amoxicillin/clavulanate has 20,388 submissions while probenecid has 268. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to probenecid slows down the kidneys from clearing amoxicillin out of your system, which can lead to higher levels of the drug in your body. it does not affect how the other part of the medicine, clavulanic acid, is removed.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between amoxicillin/clavulanate and probenecid - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.