Pioglitazone · more major-labeled pairs than Abiraterone
SPL labels Abiraterone + Pioglitazone as minor; Abiraterone 5 / Pioglitazone 9 in that band.
Mechanism on file: Abiraterone blocks a protein in the liver that normally breaks down pioglitazone. This causes pioglitazone to stay in your body longer and reach higher levels.
FDA SPL severity: Minor
Abiraterone + Pioglitazone · SPL mechanism field
Abiraterone blocks a protein in the liver that normally breaks down pioglitazone. This causes pioglitazone to stay in your body longer and reach higher levels.
Minor band excerpt · Abiraterone with Pioglitazone
In a CYP2C8 drug-drug interaction trial in healthy subjects, the AUC of pioglitazone (CYP2C8 substrate) was increased by 46% when pioglitazone was given together with a single dose of 1,000 mg abiraterone acetate.
Abiraterone · 5 minor + 7 total pairs
- Dextromethorphan minor
- Ketoconazole minor
- Prednisone minor
- Rifampin minor
Pioglitazone · 1 major-labeled pairs (vs Abiraterone's 0)
- Dapagliflozin minor
- Gemfibrozil minor
- Leflunomide minor
- Metformin/Pioglitazone minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.