What the FDA labels say about taking them together
Isoflurane and norepinephrine
Norepinephrine's FDA label of June 12, 2025 names isoflurane in its drug interactions section; the isoflurane labels PlainMeds reads (2) do not name norepinephrine.
Check it at the source: the isoflurane FDA label on DailyMed (effective January 5, 2026, Shandong New Time Pharmaceutical Co., Ltd.); the norepinephrine FDA label on DailyMed (effective June 12, 2025, Hospira, Inc.).
What does the isoflurane label say about norepinephrine?
Isoflurane's label (effective January 5, 2026) and its 1 other brand-application label do not name norepinephrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Isoflurane), Shandong New Time Pharmaceutical Co., Ltd., effective January 5, 2026 (SPL set 662ceaf6-650b-4dea-bbee-652f46426024), via openFDA; the full label on DailyMed
What does the norepinephrine label say about isoflurane?
Norepinephrine label, drug interactionsConcomitant use of LEVOPHED with halogenated anesthetics (e.g., cyclopropane, desflurane, enflurane, isoflurane, and sevoflurane) may lead to ventricular tachycardia or ventricular fibrillation.
Source: FDA drug label (Norepinephrine Bitartrate, NDA214313), Baxter Healthcare Corporation, effective February 6, 2026 (SPL set 6363e9b4-29df-4553-904d-a563e5adda6e), via openFDA
Source: FDA drug label (Norepinephrine, NDA214628), Long Grove Pharmaceuticals, LLC, effective December 4, 2025 (SPL set 759807dd-61a8-4f6f-8bf5-f6ee773c81bc), via openFDA
Source: FDA drug label (Norepinephrine Bitartrate In Sodium Chloride, NDA215700), WG Critical Care, LLC, effective February 17, 2026 (SPL set ddbef60d-c20a-4ada-928f-e87074c08a54), via openFDA
Source: FDA drug label (LEVOPHED), Hospira, Inc., effective June 12, 2025 (SPL set 2c7dd2b0-cc10-4db6-bf56-6eb154ebeb10), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isoflurane | Norepinephrine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once