What the FDA labels say about taking them together
Isoflurane and sevoflurane
Isoflurane's FDA label of January 5, 2026 names sevoflurane in its drug interactions section, and sevoflurane's label names isoflurane too.
Check it at the source: the isoflurane FDA label on DailyMed (effective January 5, 2026, Shandong New Time Pharmaceutical Co., Ltd.); the sevoflurane FDA label on DailyMed (effective February 12, 2025, AbbVie Inc.).
What does the isoflurane label say about sevoflurane?
Isoflurane label, drug interactionsIsoflurane is similar to sevoflurane in the sensitization of the myocardium to arrhythmogenic effect of exogenously administered adrenaline.
Source: FDA drug label (Forane, NDA017624), Baxter Healthcare Corporation, effective December 9, 2024 (SPL set 3d30eb8d-a62e-475f-926b-78ba63bee9c8), via openFDA
Source: FDA drug label (Isoflurane), Shandong New Time Pharmaceutical Co., Ltd., effective January 5, 2026 (SPL set 662ceaf6-650b-4dea-bbee-652f46426024), via openFDA; the full label on DailyMed
What does the sevoflurane label say about isoflurane?
Sevoflurane label, drug interactionsWhen used to supplement alfentanil-N 2 O anesthesia, sevoflurane and isoflurane equally potentiate neuromuscular block induced with pancuronium, vecuronium or atracurium.
Source: FDA drug label (Ultane), AbbVie Inc., effective February 12, 2025 (SPL set c9aa6489-5a36-44ed-9512-b996833d82f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isoflurane | Sevoflurane | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once