What the FDA labels say about taking them together

Atracurium and isoflurane

Atracurium's FDA label of December 4, 2024 names isoflurane in its drug interactions section, and isoflurane's label names atracurium too. The isoflurane label: “In general, anesthetic concentrations of FORANE at equilibrium reduce the ED 95 of succinylcholine, atracurium, pancuronium, rocuronium and vecuronium by approximately 25 to 40% or more compared to N 2 O/opioid …”

Check it at the source: the atracurium FDA label on DailyMed (effective December 4, 2024, Meitheal Pharmaceuticals Inc.); the isoflurane FDA label on DailyMed (effective January 5, 2026, Shandong New Time Pharmaceutical Co., Ltd.).

What does the atracurium label say about isoflurane?

Atracurium label, drug interactions
Drug Interactions Drugs which may enhance the neuromuscular blocking action of atracurium include: enflurane; isoflurane; halothane; certain antibiotics, especially the aminoglycosides and polymyxins; lithium; magnesium salts; procainamide; and quinidine.

Source: FDA drug label (Atracurium Besylate), Meitheal Pharmaceuticals Inc., effective December 4, 2024 (SPL set efe90ee2-fe9e-421f-9e54-2961085d3b12), via openFDA; the full label on DailyMed

What does the isoflurane label say about atracurium?

Isoflurane label, drug interactions
In general, anesthetic concentrations of isoflurane at equilibrium reduce the ED 95 of succinylcholine, atracurium, pancuronium, rocuronium and vecuronium by approximately 25 to 40% or more compared to N 2 O/opioid anesthesia.

Source: FDA drug label (Forane, NDA017624), Baxter Healthcare Corporation, effective December 9, 2024 (SPL set 3d30eb8d-a62e-475f-926b-78ba63bee9c8), via openFDA

Source: FDA drug label (Isoflurane), Shandong New Time Pharmaceutical Co., Ltd., effective January 5, 2026 (SPL set 662ceaf6-650b-4dea-bbee-652f46426024), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

3Atracurium generic labelers

5Isoflurane generic labelers

	Atracurium	Isoflurane
Labeled for	n/a	n/a
Boxed warning	No	No
Pharmacy cost (NADAC)	n/a	n/a
Shortage now	No current entry	No current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?

Atracurium: the full record
Isoflurane: the full record
Check more medicines together: up to five at once