PlainMeds rankings

FAERS reports coded as a death, by medicine (counts, not causes)

FAERS reports with the seriousness code death, through July 30, 2026. The most: oxycodone (74,855 reports). A FAERS report does not show that the medicine caused the event; counts follow use and reporting. Medicines used by very ill people (cancer, intensive care) carry more death-coded reports for that reason.

The ranking

Rank	Medicine	Reports
1	Oxycodone	74,855
2	Acetaminophen	62,472
3	Furosemide	61,850
4	Lenalidomide	53,763
5	Prednisone	52,155
6	Dexamethasone	49,353
7	Aspirin	48,992
8	Amlodipine	42,260
9	Omeprazole	39,203
10	Metoprolol	38,371
11	Rituximab	37,918
12	Methotrexate	37,720
13	Pantoprazole	36,440
14	Cyclophosphamide	35,641
15	Morphine	34,831
16	Gabapentin	34,219
17	Metformin	33,853
18	Fentanyl	33,716
19	Alprazolam	33,446
20	Omeprazole and sodium bicarbonate	31,161
21	Adalimumab	30,985
22	Prednisolone	29,606
23	Bevacizumab	28,571
24	Quetiapine	28,195
25	Hydromorphone	28,105
26	Methylprednisolone	27,470
27	Buprenorphine	27,352
28	Rivaroxaban	27,139
29	Tacrolimus	25,784
30	Lorazepam	25,768
31	Denosumab	25,734
32	Lisinopril	25,263
33	Isopropyl alcohol	24,766
34	Nivolumab	24,663
35	Alcohol	24,471
36	Mycophenolate mofetil	24,305
37	Clopidogrel	23,381
38	Folic acid	23,149
39	Diazepam	22,964
40	Ergocalciferol	22,811
41	Diphenhydramine	22,785
42	Clozapine	22,310
43	Simvastatin	22,213
44	Pregabalin	22,084
45	Allopurinol	21,961
46	Hydrocodone	21,422
47	Tapentadol	20,613
48	Carboplatin	20,032
49	Lansoprazole	19,914
50	Darbepoetin alfa	19,851
51	Esomeprazole	19,686
52	Levothyroxine	19,275
53	Citalopram	18,996
54	Sertraline	18,962
55	Pembrolizumab	18,742
56	Atorvastatin	18,672
57	Clonazepam	18,605
58	Albuterol	18,583
59	Sildenafil	18,360
60	Ibuprofen	18,314

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, read October 8, 2026

What it cannot show

A FAERS report does not show that the medicine caused the event; counts follow use and reporting. Medicines used by very ill people (cancer, intensive care) carry more death-coded reports for that reason.