Vilazodone and Warfarin Interaction
Drug interaction information between Vilazodone and Warfarin.
Vilazodone and Warfarin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Vilazodone and Warfarin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Vilazodone is a type of antidepressant that can increase the risk of bleeding when taken with blood thinners. This happens because the drug can interfere with the normal clotting process.
What To Do
Use this combination with caution and under a doctor's supervision. Monitor yourself for signs of bleeding, such as nosebleeds or bleeding gums.
Vilazodone Also Interacts With
- Linezolid major
- Tranylcypromine major
- Carbamazepine minor
- Clarithromycin minor
- Rifampin minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
Can I take Vilazodone and Warfarin together?
This is a moderate interaction. Use this combination with caution and under a doctor's supervision. Monitor yourself for signs of bleeding, such as nosebleeds or bleeding gums.
How serious is the interaction between Vilazodone and Warfarin?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Vilazodone and Warfarin interact?
Vilazodone is a type of antidepressant that can increase the risk of bleeding when taken with blood thinners. This happens because the drug can interfere with the normal clotting process.
Understanding the Vilazodone and Warfarin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Vilazodone belongs to the SSRI / 5-HT1A Partial Agonist class and Warfarin belongs to the Vitamin K Antagonist (Anticoagulant) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Vilazodone is a type of antidepressant that can increase the risk of bleeding when taken with blood thinners. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Vilazodone has 10 total documented interactions on file in this dataset, and Warfarin has 163. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Use this combination with caution and under a doctor's supervision. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Vilazodone or Warfarin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.