Vilazodone and Warfarin Interaction
Drug interaction information between Vilazodone and Warfarin.
Vilazodone and Warfarin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Vilazodone and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Vilazodone is a type of antidepressant that can increase the risk of bleeding when taken with blood thinners. This happens because the drug can interfere with the normal clotting process.
Vilazodone Also Interacts With
- Linezolid major
- Tranylcypromine major
- Carbamazepine minor
- Clarithromycin minor
- Rifampin minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Vilazodone + Warfarin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Vilazodone's 10. In the moderate band specifically: Vilazodone has 1; Warfarin has 28 (also Ibuprofen, Aspirin, Diclofenac, Desvenlafaxine).
What mechanism field is on file for Vilazodone and Warfarin?
Vilazodone is a type of antidepressant that can increase the risk of bleeding when taken with blood thinners. This happens because the drug can interfere with the normal clotting process.
Warfarin's labeled portfolio outnumbers Vilazodone
SPL source-record counts only. This page's band is moderate · classes on file: Vilazodone (SSRI / 5-HT1A Partial Agonist); Warfarin (Vitamin K Antagonist (Anticoagulant)).
2 major · 1 moderate · 7 minor · 10 total
Vilazodone has no other moderate-band peer in this dataset besides Warfarin.
2 major · 28 moderate · 133 minor · 163 total
- Other moderate peers for Warfarin
- Ibuprofen
- Aspirin
- Diclofenac
- Desvenlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.