Vilazodone and Rifampin Interaction
Drug interaction information between Vilazodone and Rifampin.
Vilazodone and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Vilazodone and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin causes your body to process and remove vilazodone much faster than normal. This can lower the amount of medicine in your blood and make it work less effectively.
FDA Label Information
Strong CYP3A4 Inducers (e.g., carbamazepine, phenytoin, rifampin) The concomitant use of vilazodone hydrochloride tablets and strong CYP3A4 inducers decreased the exposure of vilazodone compared to the use of vilazodone hydrochloride tablets alone [see Clinical Pharmacology (12.3)].
Vilazodone Also Interacts With
- Linezolid major
- Tranylcypromine major
- Warfarin moderate
- Carbamazepine minor
- Clarithromycin minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Vilazodone + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Vilazodone's 10. In the minor band specifically: Vilazodone has 7 (also Carbamazepine, Clarithromycin, Itraconazole, Voriconazole); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Vilazodone and Rifampin?
Rifampin causes your body to process and remove vilazodone much faster than normal. This can lower the amount of medicine in your blood and make it work less effectively.
Rifampin carries more major-labeled pairs than Vilazodone
SPL source-record counts only. This page's band is minor · classes on file: Vilazodone (SSRI / 5-HT1A Partial Agonist); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Vilazodone's 2. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 7 minor · 10 total
- Other minor peers for Vilazodone
- Carbamazepine
- Clarithromycin
- Itraconazole
- Voriconazole
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.