Vilazodone and Linezolid Interaction
Drug interaction information between Vilazodone and Linezolid.
Vilazodone and Linezolid have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Vilazodone and Linezolid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs increase the amount of serotonin in your brain. Taking them together can cause serotonin levels to become dangerously high, which can be life-threatening.
FDA Label Information
Vilazodone hydrochloride tablets are contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [see Contraindications (4), Dosage and Administration (2.3), and Warnings and Precautions (5.2)].
Vilazodone Also Interacts With
- Tranylcypromine major
- Warfarin moderate
- Carbamazepine minor
- Clarithromycin minor
- Rifampin minor
Linezolid Also Interacts With
- Citalopram major
- Escitalopram major
- Mirtazapine major
- Paroxetine major
- Safinamide major
Frequently Asked Questions
What SPL severity band is on file for Vilazodone + Linezolid?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Linezolid has 29 labeled pairs on file vs Vilazodone's 10. In the major band specifically: Vilazodone has 2 (also Tranylcypromine); Linezolid has 8 (also Citalopram, Escitalopram, Mirtazapine, Paroxetine).
What mechanism field is on file for Vilazodone and Linezolid?
Both of these drugs increase the amount of serotonin in your brain. Taking them together can cause serotonin levels to become dangerously high, which can be life-threatening.
Linezolid carries more major-labeled pairs than Vilazodone
SPL source-record counts only. This page's band is major · classes on file: Vilazodone (SSRI / 5-HT1A Partial Agonist); Linezolid (Oxazolidinone Antibiotic).
Linezolid has 8 major-labeled pairs vs Vilazodone's 2.
2 major · 1 moderate · 7 minor · 10 total
- Other major peers for Vilazodone
- Tranylcypromine
8 major · 3 moderate · 18 minor · 29 total
- Other major peers for Linezolid
- Citalopram
- Escitalopram
- Mirtazapine
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.