Vilazodone and Tranylcypromine Interaction
Drug interaction information between Vilazodone and Tranylcypromine.
Vilazodone and Tranylcypromine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Vilazodone and Tranylcypromine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs increase serotonin levels in the brain, which can lead to a dangerous and life-threatening condition called serotonin syndrome.
FDA Label Information
Excessive reduction of blood glucose (additive effect) [See Warnings and Precautions (5.14)] ; CNS depressant agents (including opioids, alcohol, sedatives, hypnotics) Use with caution Increased CNS depression Dietary supplements containing sympathomimetics Contraindicated Antidepressants including but not limited to: • Other MAOIs (e.g., linezolid, intravenous methylene blue, selective MAOIs) • Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) • Tricyclic antidepressants • Amoxapine, bupropion, maprotiline, nefazodone, trazodone,...
Vilazodone Also Interacts With
- Linezolid major
- Warfarin moderate
- Carbamazepine minor
- Clarithromycin minor
- Rifampin minor
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Epinephrine major
- Norepinephrine major
- Phenylephrine major
Frequently Asked Questions
What SPL severity band is on file for Vilazodone + Tranylcypromine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Vilazodone's 10. In the major band specifically: Vilazodone has 2 (also Linezolid); Tranylcypromine has 7 (also Bupropion, Linezolid, Epinephrine, Norepinephrine).
What mechanism field is on file for Vilazodone and Tranylcypromine?
Both drugs increase serotonin levels in the brain, which can lead to a dangerous and life-threatening condition called serotonin syndrome.
Tranylcypromine carries more major-labeled pairs than Vilazodone
SPL source-record counts only. This page's band is major · classes on file: Vilazodone (SSRI / 5-HT1A Partial Agonist); Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)).
Tranylcypromine has 7 major-labeled pairs vs Vilazodone's 2.
7 major · 23 moderate · 12 minor · 42 total
- Other major peers for Tranylcypromine
- Bupropion
- Linezolid
- Epinephrine
- Norepinephrine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.