Vilazodone and Clarithromycin Interaction
Drug interaction information between Vilazodone and Clarithromycin.
Vilazodone and Clarithromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Vilazodone and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin slows down the liver enzymes that break down vilazodone. This causes the amount of vilazodone in your blood to rise, which could increase the risk of side effects.
FDA Label Information
Strong CYP3A4 Inhibitors (e.g., itraconazole, clarithromycin, voriconazole) The concomitant use of vilazodone hydrochloride tablets and strong CYP3A4 inhibitors increased the exposure of vilazodone compared to the use of vilazodone hydrochloride tablets alone [see Clinical Pharmacology (12.3)].
Vilazodone Also Interacts With
- Linezolid major
- Tranylcypromine major
- Warfarin moderate
- Carbamazepine minor
- Rifampin minor
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Vilazodone + Clarithromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Vilazodone's 10. In the minor band specifically: Vilazodone has 7 (also Carbamazepine, Rifampin, Itraconazole, Voriconazole); Clarithromycin has 30 (also Amlodipine, Lorazepam, Diltiazem, Erythromycin).
What mechanism field is on file for Vilazodone and Clarithromycin?
Clarithromycin slows down the liver enzymes that break down vilazodone. This causes the amount of vilazodone in your blood to rise, which could increase the risk of side effects.
Clarithromycin carries more major-labeled pairs than Vilazodone
SPL source-record counts only. This page's band is minor · classes on file: Vilazodone (SSRI / 5-HT1A Partial Agonist); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Vilazodone's 2. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 7 minor · 10 total
- Other minor peers for Vilazodone
- Carbamazepine
- Rifampin
- Itraconazole
- Voriconazole
16 major · 35 moderate · 30 minor · 81 total
- Other minor peers for Clarithromycin
- Amlodipine
- Lorazepam
- Diltiazem
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.