tranylcypromine vs vilazodone
Side-by-side comparison of tranylcypromine and vilazodone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Excessive reduction of blood glucose (additive effect) [See Warnings and Precautions (5.14)] ; CNS depressant agents (including opioids, alcohol, sedatives, hypnotics) Use with caution Increased CNS depression Dietary supplements containing sympathomimetics Contraindicated Antidepressants including but not limited to: • Other MAOIs (e.g., linezolid, intravenous methylene blue, selective MAOIs) • Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) • Tricyclic antidepressants • Amoxapine, bupropion, maprotiline, nefazodone, trazodone,...
Recommendation: Do not take these medications together. Your doctor will typically require a waiting period of at least 14 days when switching between them.
Parnate
Viibryd
Tranylcypromine (Parnate) is a medicine used to treat major depression in adults. It is used when other antidepressants have not worked well enough.
Vilazodone (Viibryd) is a medicine used to treat depression in adults. It helps to improve your mood.
Tranylcypromine is used to treat major depressive disorder (MDD) in adults. You should only use it if other antidepressants haven't helped. It is not for the first treatment of depression because it can cause serious side effects and has many drug and food interactions.
Vilazodone is used to treat major depressive disorder (MDD) in adults. MDD can cause you to feel sad, lose interest in activities, and have trouble with daily life. This medicine can help improve these symptoms.
Tranylcypromine belongs to a class of drugs called MAO inhibitors. It works by increasing the levels of certain chemicals in your brain. These chemicals can help improve your mood.
Vilazodone works by affecting certain chemicals in the brain. It increases the amount of serotonin available. Serotonin helps to regulate mood and emotions.
- • Dry mouth
- • Dizziness
- • Trouble sleeping
- • Feeling sleepy
- • Headache
- • Diarrhea
- • Nausea
- • Vomiting
- • Trouble sleeping (insomnia)
- Interaction between medicines 68
- Feeling sad or hopeless 36
- Too much serotonin in the body 27
- Head pain 24
- High blood pressure 24
- Diarrhea 808
- Nausea 808
- Anxiety 662
- Trouble sleeping 634
- Headache 565
Tranylcypromine can increase the risk of suicidal thoughts and behaviors in young adults. It can also cause a dangerous increase in blood pressure if you eat foods high in tyramine or take certain medicines. Make sure to follow all food and drug restrictions.
Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults. Your doctor should closely monitor you for worsening depression or suicidal thoughts, especially when you first start taking this medicine or when your dose is changed. Vilazodone is not approved for use in children.
There is limited information about the safety of tranylcypromine during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not recommended to breastfeed while taking this medicine because it can harm the baby.
Tell your doctor if you are pregnant or plan to become pregnant. Taking vilazodone late in pregnancy may cause problems for the newborn. There is a pregnancy registry to monitor outcomes in women exposed to antidepressants during pregnancy. You can call 1-844-405-6185 to register.
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How to Read This tranylcypromine vs vilazodone Comparison
tranylcypromine is classified in the Monoamine Oxidase Inhibitor (MAOI) drug class, while vilazodone sits within the SSRI / 5-HT1A Partial Agonist class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, tranylcypromine has 179 submissions while vilazodone has 3,477. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to both drugs increase serotonin levels in the brain, which can lead to a dangerous and life-threatening condition called serotonin syndrome.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between tranylcypromine and vilazodone - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.