Terbinafine and Fluconazole Interaction
Drug interaction information between Terbinafine and Fluconazole.
Terbinafine and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Terbinafine and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole interferes with the way the body processes terbinafine, leading to higher amounts of terbinafine in the bloodstream.
FDA Label Information
Drug interactions have also been noted with cimetidine, fluconazole, cyclosporine, rifampin, and caffeine. The influence of terbinafine on the pharmacokinetics of fluconazole, cotrimoxazole (trimethoprim and sulfamethoxazole), zidovudine or theophylline was not considered to be clinically significant. Coadministration of a single dose of fluconazole (100 mg) with a single dose of terbinafine resulted in a 52% and 69% increase in terbinafine C max and AUC, respectively.
Terbinafine Also Interacts With
- Tamsulosin moderate
- Ketoconazole minor
- Cyclosporine minor
- Trimethoprim minor
- Rifampin minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Terbinafine + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Terbinafine's 17. In the minor band specifically: Terbinafine has 16 (also Ketoconazole, Cyclosporine, Trimethoprim, Rifampin); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Terbinafine and Fluconazole?
Fluconazole interferes with the way the body processes terbinafine, leading to higher amounts of terbinafine in the bloodstream.
Fluconazole carries more major-labeled pairs than Terbinafine
SPL source-record counts only. This page's band is minor · classes on file: Terbinafine (Allylamine Antifungal); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Terbinafine's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 16 minor · 17 total
- Other minor peers for Terbinafine
- Ketoconazole
- Cyclosporine
- Trimethoprim
- Rifampin
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.