Terbinafine and Rifampin Interaction
Drug interaction information between Terbinafine and Rifampin.
Terbinafine and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Terbinafine and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin triggers the body to break down terbinafine twice as fast as usual.
FDA Label Information
Drug interactions have also been noted with cimetidine, fluconazole, cyclosporine, rifampin, and caffeine. Terbinafine clearance is increased 100% by rifampin, a CYP450 enzyme inducer, and decreased 33% by cimetidine, a CYP450 enzyme inhibitor.
Terbinafine Also Interacts With
- Tamsulosin moderate
- Ketoconazole minor
- Fluconazole minor
- Cyclosporine minor
- Trimethoprim minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Terbinafine + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Terbinafine's 17. In the minor band specifically: Terbinafine has 16 (also Ketoconazole, Fluconazole, Cyclosporine, Trimethoprim); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Terbinafine and Rifampin?
Rifampin triggers the body to break down terbinafine twice as fast as usual.
Rifampin carries more major-labeled pairs than Terbinafine
SPL source-record counts only. This page's band is minor · classes on file: Terbinafine (Allylamine Antifungal); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Terbinafine's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 16 minor · 17 total
- Other minor peers for Terbinafine
- Ketoconazole
- Fluconazole
- Cyclosporine
- Trimethoprim
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.