What the FDA labels say about taking them together
Cyclosporine and terbinafine
Cyclosporine's FDA label of August 10, 2026 names terbinafine in its drug interactions section, and terbinafine's label names cyclosporine too. The cyclosporine label: “… oxcarbazepine octreotide phenobarbital orlistat phenytoin sulfinpyrazone terbinafine ticlopidine Bosentan Concomitant use of bosentan and cyclosporine for 7 days in healthy subjects resulted in decreases in the …”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the terbinafine FDA label on DailyMed (effective October 17, 2025, PD-Rx Pharmaceuticals, Inc.).
What does the cyclosporine label say about terbinafine?
Cyclosporine label, drug interactionsDrugs/Dietary Supplements That Decrease Cyclosporine Concentrations Antibiotics Anticonvulsants Other Drugs/Dietary Supplements nafcillin carbamazepine bosentan St. John’s Wort rifampin oxcarbazepine octreotide phenobarbital orlistat phenytoin sulfinpyrazone terbinafine ticlopidine Bosentan Coadministration of bosentan (250 to 1000 mg every 12 hours based on tolerability) and cyclosporine (300 mg every 12 hours for 2 days then dosing to achieve a C min of 200 to 250 ng/mL) for 7 days in healthy subjects resulted in decreases in the cyclosporine mean dose-normalized AUC, C max, and trough concentration of approximately 50%, 30%, and 60%, respectively, compared to when cyclosporine was given …
Source: FDA drug label (Sandimmune, NDA050573), Novartis Pharmaceuticals Corporation, effective July 10, 2026 (SPL set 5e5926a7-1de0-4b54-a5c0-286b6200ff82), via openFDA
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the terbinafine label say about cyclosporine?
Terbinafine label, drug interactionsIn vitro studies with human liver microsomes showed that terbinafine does not inhibit the metabolism of tolbutamide, ethinylestradiol, ethoxycoumarin, cyclosporine, cisapride and fluvastatin.
Source: FDA drug label (Terbinafine Hydrochloride), PD-Rx Pharmaceuticals, Inc., effective October 17, 2025 (SPL set 2df111dc-ecac-4161-9e22-38436eb37c1f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Terbinafine | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.143 per tablet 250 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once