Terbinafine and Cyclosporine Interaction
Drug interaction information between Terbinafine and Cyclosporine.
Terbinafine and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Terbinafine and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Terbinafine makes the body get rid of cyclosporine more quickly than normal.
FDA Label Information
Drug interactions have also been noted with cimetidine, fluconazole, cyclosporine, rifampin, and caffeine. In vitro studies with human liver microsomes showed that terbinafine does not inhibit the metabolism of tolbutamide, ethinylestradiol, ethoxycoumarin, cyclosporine, cisapride and fluvastatin. Terbinafine increases the clearance of cyclosporine by 15%.
Terbinafine Also Interacts With
- Tamsulosin moderate
- Ketoconazole minor
- Fluconazole minor
- Trimethoprim minor
- Rifampin minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Terbinafine + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Terbinafine's 17. In the minor band specifically: Terbinafine has 16 (also Ketoconazole, Fluconazole, Trimethoprim, Rifampin); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Terbinafine and Cyclosporine?
Terbinafine makes the body get rid of cyclosporine more quickly than normal.
Cyclosporine carries more major-labeled pairs than Terbinafine
SPL source-record counts only. This page's band is minor · classes on file: Terbinafine (Allylamine Antifungal); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Terbinafine's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 16 minor · 17 total
- Other minor peers for Terbinafine
- Ketoconazole
- Fluconazole
- Trimethoprim
- Rifampin
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.