Tasimelteon and Metoprolol Interaction
Drug interaction information between Tasimelteon and Metoprolol.
Tasimelteon and Metoprolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tasimelteon and Metoprolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This heart medicine can lower the amount of natural sleep chemicals your body produces. This may stop the sleep medicine from working as well as it should.
FDA Label Information
7.3 Beta-Adrenergic Receptor Antagonists (e.g., acebutolol, metoprolol) Beta-adrenergic receptor antagonists have been shown to reduce the production of melatonin via specific inhibition of beta-1 adrenergic receptors.
Tasimelteon Also Interacts With
- Rifampin moderate
- Fluvoxamine moderate
- Melatonin minor
- Acebutolol minor
Metoprolol Also Interacts With
- Theophylline major
- Clonidine moderate
- Diltiazem moderate
- Verapamil moderate
- Fluoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Tasimelteon + Metoprolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metoprolol has 18 labeled pairs on file vs Tasimelteon's 5. In the minor band specifically: Tasimelteon has 3 (also Melatonin, Acebutolol); Metoprolol has 14 (also Fluoxetine, Paroxetine, Propafenone, Epinephrine).
What mechanism field is on file for Tasimelteon and Metoprolol?
This heart medicine can lower the amount of natural sleep chemicals your body produces. This may stop the sleep medicine from working as well as it should.
Metoprolol carries more major-labeled pairs than Tasimelteon
SPL source-record counts only. This page's band is minor · classes on file: Tasimelteon (Melatonin Receptor Agonist); Metoprolol (Beta-Blocker).
Metoprolol has 1 major-labeled pair vs Tasimelteon's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 3 minor · 5 total
- Other minor peers for Tasimelteon
- Melatonin
- Acebutolol
1 major · 3 moderate · 14 minor · 18 total
- Other minor peers for Metoprolol
- Fluoxetine
- Paroxetine
- Propafenone
- Epinephrine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.