What the FDA labels say about taking them together
Metoprolol and tasimelteon
Tasimelteon's FDA label of August 4, 2026 names metoprolol in its drug interactions section; the metoprolol labels PlainMeds reads (4) do not name tasimelteon. The tasimelteon label: “Antagonists Beta-adrenergic receptor antagonists have been shown to reduce the production of melatonin via specific inhibition of beta-1 adrenergic receptors.”
Check it at the source: the metoprolol FDA label on DailyMed (effective March 3, 2026, Melinta Therapeutics, LLC); the tasimelteon FDA label on DailyMed (effective August 4, 2026, Vanda Pharmaceuticals Inc.).
What does the metoprolol label say about tasimelteon?
Metoprolol's label (effective March 3, 2026) and its 3 other brand-application labels do not name tasimelteon in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TOPROL XL), Melinta Therapeutics, LLC, effective March 3, 2026 (SPL set 496ddfaa-7c9c-4888-b747-a210249b367a), via openFDA; the full label on DailyMed
What does the tasimelteon label say about metoprolol?
Tasimelteon label, drug interactionsAntagonists (e.g., acebutolol, metoprolol) Beta-adrenergic receptor antagonists have been shown to reduce the production of melatonin via specific inhibition of beta-1 adrenergic receptors.
Source: FDA drug label (Hetlioz), Vanda Pharmaceuticals Inc., effective August 4, 2026 (SPL set ca4a9b63-708e-49e9-8f9b-010625443b90), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Metoprolol | Tasimelteon | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Heart failure, Heart attack and coronary artery disease | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.085 per tablet 100 mg tablet | $228.25 per capsule 20 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once