Tasimelteon and Melatonin Interaction
Drug interaction information between Tasimelteon and Melatonin.
Tasimelteon and Melatonin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tasimelteon and Melatonin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these products target the same sleep receptors in your brain. Using them together could cause excessive sleepiness or change how the prescription medicine works.
FDA Label Information
7.3 Beta-Adrenergic Receptor Antagonists (e.g., acebutolol, metoprolol) Beta-adrenergic receptor antagonists have been shown to reduce the production of melatonin via specific inhibition of beta-1 adrenergic receptors.
Tasimelteon Also Interacts With
- Rifampin moderate
- Fluvoxamine moderate
- Metoprolol minor
- Acebutolol minor
Frequently Asked Questions
What SPL severity band is on file for Tasimelteon + Melatonin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tasimelteon has 5 labeled pairs on file vs Melatonin's 2. In the minor band specifically: Tasimelteon has 3 (also Metoprolol, Acebutolol); Melatonin has 2 (also Lisdexamfetamine).
What mechanism field is on file for Tasimelteon and Melatonin?
Both of these products target the same sleep receptors in your brain. Using them together could cause excessive sleepiness or change how the prescription medicine works.
Tasimelteon's labeled portfolio outnumbers Melatonin
SPL source-record counts only. This page's band is minor · classes on file: Tasimelteon (Melatonin Receptor Agonist); Melatonin (Hormone Supplement (Sleep Aid)).
0 major · 2 moderate · 3 minor · 5 total
- Other minor peers for Tasimelteon
- Metoprolol
- Acebutolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.