Tasimelteon and Melatonin Interaction
Drug interaction information between Tasimelteon and Melatonin.
Tasimelteon and Melatonin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tasimelteon and Melatonin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these products target the same sleep receptors in your brain. Using them together could cause excessive sleepiness or change how the prescription medicine works.
What To Do
Talk to your doctor before taking over-the-counter melatonin with this prescription sleep medicine. They may advise you to avoid using both at the same time.
FDA Label Information
7.3 Beta-Adrenergic Receptor Antagonists (e.g., acebutolol, metoprolol) Beta-adrenergic receptor antagonists have been shown to reduce the production of melatonin via specific inhibition of beta-1 adrenergic receptors.
Tasimelteon Also Interacts With
- Rifampin moderate
- Fluvoxamine moderate
- Metoprolol minor
- Acebutolol minor
Frequently Asked Questions
Can I take Tasimelteon and Melatonin together?
This is a minor interaction. Talk to your doctor before taking over-the-counter melatonin with this prescription sleep medicine. They may advise you to avoid using both at the same time.
How serious is the interaction between Tasimelteon and Melatonin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Tasimelteon and Melatonin interact?
Both of these products target the same sleep receptors in your brain. Using them together could cause excessive sleepiness or change how the prescription medicine works.
Understanding the Tasimelteon and Melatonin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Tasimelteon belongs to the Melatonin Receptor Agonist class and Melatonin belongs to the Hormone Supplement (Sleep Aid) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these products target the same sleep receptors in your brain. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Tasimelteon has 5 total documented interactions on file in this dataset, and Melatonin has 2. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Talk to your doctor before taking over-the-counter melatonin with this prescription sleep medicine. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Tasimelteon or Melatonin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.