What the FDA labels say about taking them together
Fluvoxamine and tasimelteon
Tasimelteon's FDA label of August 4, 2026 names fluvoxamine in its drug interactions section; the fluvoxamine labels PlainMeds reads (2) do not name tasimelteon. The tasimelteon label: “DRUG INTERACTIONS Strong CYP1A2 inhibitors (e.g., fluvoxamine): Avoid use of HETLIOZ in combination with strong CYP1A2 inhibitors because of increased exposure Strong CYP3A4 inducers (e.g., rifampin):”
Check it at the source: the fluvoxamine FDA label on DailyMed (effective June 27, 2026, Zydus Pharmaceuticals USA Inc.); the tasimelteon FDA label on DailyMed (effective August 4, 2026, Vanda Pharmaceuticals Inc.).
What does the fluvoxamine label say about tasimelteon?
Fluvoxamine's label (effective June 27, 2026) and its 1 other brand-application label do not name tasimelteon in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fluvoxamine maleate extended-release), Zydus Pharmaceuticals USA Inc., effective June 27, 2026 (SPL set 6c71d4f6-54b5-4d3a-8d2f-b7773c92c32e), via openFDA; the full label on DailyMed
What does the tasimelteon label say about fluvoxamine?
Tasimelteon label, drug interactionsDRUG INTERACTIONS Strong CYP1A2 inhibitors (e.g., fluvoxamine): Avoid use of HETLIOZ in combination with strong CYP1A2 inhibitors because of increased exposure ( 7.1 , 12.3 ) Strong CYP3A4 inducers (e.g., rifampin):
Source: FDA drug label (Hetlioz), Vanda Pharmaceuticals Inc., effective August 4, 2026 (SPL set ca4a9b63-708e-49e9-8f9b-010625443b90), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluvoxamine | Tasimelteon | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $4.08 per capsule 100 mg capsule | $228.25 per capsule 20 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once