Tasimelteon and Fluvoxamine Interaction
Drug interaction information between Tasimelteon and Fluvoxamine.
Tasimelteon and Fluvoxamine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Tasimelteon and Fluvoxamine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluvoxamine blocks the enzyme that normally breaks down tasimelteon. This causes tasimelteon to build up in your body, which increases the risk of side effects.
FDA Label Information
7 DRUG INTERACTIONS Strong CYP1A2 inhibitors (e.g., fluvoxamine): Avoid use of tasimelteon in combination with strong CYP1A2 inhibitors because of increased exposure ( 7.1 , 12.3 ) Strong CYP3A4 inducers (e.g., rifampin): Avoid use of tasimelteon in combination with rifampin or other CYP3A4 inducers, because of decreased exposure ( 7.2 , 12.3 ) 7.1 Strong CYP1A2 Inhibitors (e.g., fluvoxamine) Avoid use of tasimelteon in combination with fluvoxamine or other strong CYP1A2 inhibitors because of a potentially large increase in tasimelteon exposure and greater risk of adverse reactions [see...
Tasimelteon Also Interacts With
- Rifampin moderate
- Metoprolol minor
- Melatonin minor
- Acebutolol minor
Fluvoxamine Also Interacts With
- Tizanidine major
- Lithium moderate
- Phenelzine moderate
- Metoprolol minor
- Omeprazole minor
Frequently Asked Questions
What SPL severity band is on file for Tasimelteon + Fluvoxamine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluvoxamine has 40 labeled pairs on file vs Tasimelteon's 5. In the moderate band specifically: Tasimelteon has 2 (also Rifampin); Fluvoxamine has 3 (also Lithium, Phenelzine).
What mechanism field is on file for Tasimelteon and Fluvoxamine?
Fluvoxamine blocks the enzyme that normally breaks down tasimelteon. This causes tasimelteon to build up in your body, which increases the risk of side effects.
Fluvoxamine carries more major-labeled pairs than Tasimelteon
SPL source-record counts only. This page's band is moderate · classes on file: Tasimelteon (Melatonin Receptor Agonist); Fluvoxamine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluvoxamine has 1 major-labeled pair vs Tasimelteon's 0. This page itself is in the moderate band, not the major band.
1 major · 3 moderate · 36 minor · 40 total
- Other moderate peers for Fluvoxamine
- Lithium
- Phenelzine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.