Tasimelteon and Acebutolol Interaction
Drug interaction information between Tasimelteon and Acebutolol.
Tasimelteon and Acebutolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tasimelteon and Acebutolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Acebutolol can lower the amount of natural melatonin your body makes. This may make tasimelteon less effective since it works on the same sleep system.
FDA Label Information
7.3 Beta-Adrenergic Receptor Antagonists (e.g., acebutolol, metoprolol) Beta-adrenergic receptor antagonists have been shown to reduce the production of melatonin via specific inhibition of beta-1 adrenergic receptors.
Tasimelteon Also Interacts With
- Rifampin moderate
- Fluvoxamine moderate
- Metoprolol minor
- Melatonin minor
Frequently Asked Questions
What SPL severity band is on file for Tasimelteon + Acebutolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tasimelteon has 5 labeled pairs on file vs Acebutolol's 1. In the minor band specifically: Tasimelteon has 3 (also Metoprolol, Melatonin); Acebutolol has 1.
What mechanism field is on file for Tasimelteon and Acebutolol?
Acebutolol can lower the amount of natural melatonin your body makes. This may make tasimelteon less effective since it works on the same sleep system.
Tasimelteon's labeled portfolio outnumbers Acebutolol
SPL source-record counts only. This page's band is minor · classes on file: Tasimelteon (Melatonin Receptor Agonist); Acebutolol (Beta-1 Selective Blocker with ISA).
0 major · 2 moderate · 3 minor · 5 total
- Other minor peers for Tasimelteon
- Metoprolol
- Melatonin
0 major · 0 moderate · 1 minor · 1 total
Acebutolol has no other minor-band peer in this dataset besides Tasimelteon.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.