Tasimelteon and Acebutolol Interaction
Drug interaction information between Tasimelteon and Acebutolol.
Tasimelteon and Acebutolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tasimelteon and Acebutolol. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Acebutolol can lower the amount of natural melatonin your body makes. This may make tasimelteon less effective since it works on the same sleep system.
What To Do
Your doctor may need to monitor your sleep patterns or adjust your medications if they are not working well.
FDA Label Information
7.3 Beta-Adrenergic Receptor Antagonists (e.g., acebutolol, metoprolol) Beta-adrenergic receptor antagonists have been shown to reduce the production of melatonin via specific inhibition of beta-1 adrenergic receptors.
Tasimelteon Also Interacts With
- Rifampin moderate
- Fluvoxamine moderate
- Metoprolol minor
- Melatonin minor
Frequently Asked Questions
Can I take Tasimelteon and Acebutolol together?
This is a minor interaction. Your doctor may need to monitor your sleep patterns or adjust your medications if they are not working well.
How serious is the interaction between Tasimelteon and Acebutolol?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Tasimelteon and Acebutolol interact?
Acebutolol can lower the amount of natural melatonin your body makes. This may make tasimelteon less effective since it works on the same sleep system.
Understanding the Tasimelteon and Acebutolol Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Tasimelteon belongs to the Melatonin Receptor Agonist class and Acebutolol belongs to the Beta-1 Selective Blocker with ISA class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Acebutolol can lower the amount of natural melatonin your body makes. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Tasimelteon has 5 total documented interactions on file in this dataset, and Acebutolol has 1. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to monitor your sleep patterns or adjust your medications if they are not working well. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Tasimelteon or Acebutolol based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.