metoprolol vs tasimelteon
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Side-by-side comparison of metoprolol and tasimelteon. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.3 Beta-Adrenergic Receptor Antagonists (e.g., acebutolol, metoprolol) Beta-adrenergic receptor antagonists have been shown to reduce the production of melatonin via specific inhibition of beta-1 adrenergic receptors.
Lopressor, Toprol-XL
Hetlioz
Metoprolol is a beta-blocker medicine. It can lower blood pressure, reduce chest pain, and improve survival after a heart attack.
Tasimelteon (Hetlioz) is a medicine that helps people with Non-24-Hour Sleep-Wake Disorder (Non-24) sleep better. It works by acting like melatonin in your body.
Metoprolol treats high blood pressure (hypertension). Lowering blood pressure reduces the risk of strokes and heart attacks. It also treats chest pain called angina. After a heart attack, it can help you live longer.
Tasimelteon is used to treat Non-24-Hour Sleep-Wake Disorder (Non-24) in adults. Non-24 is a condition where your body's natural sleep-wake cycle is longer than 24 hours. This medicine can help you sleep better at night.
Metoprolol blocks the effects of adrenaline on the heart. This makes the heart beat slower and with less force. As a result, blood pressure is lowered and the heart does not need as much oxygen.
Tasimelteon is a melatonin receptor agonist. This means it works like melatonin, a natural hormone in your body that helps regulate sleep. By acting like melatonin, tasimelteon helps to adjust your body's sleep-wake cycle.
- • Tiredness
- • Dizziness
- • Depression
- • Shortness of breath
- • Slow heart rate
- • Headache
- • Increased liver enzyme (alanine aminotransferase)
- • Nightmares or unusual dreams
- • Upper respiratory tract infection
- • Urinary tract infection
- Fatigue 15,966
- Dyspnoea 14,128
- Diarrhoea 13,635
- Nausea 13,398
- Dizziness 11,699
- Insomnia 727
- Middle Insomnia 412
- Somnolence 408
- Headache 384
- Nightmare 268
Stopping metoprolol suddenly can make chest pain worse or cause a heart attack. If you have heart failure, it could get worse. If you have asthma or other lung problems, avoid beta-blockers if possible.
After taking tasimelteon, limit your activities to getting ready for bed. This medicine can make you sleepy and affect your ability to think clearly.
Tell your doctor if you are pregnant or plan to become pregnant. Metoprolol can cross the placenta, and may cause low blood pressure, low blood sugar, and a slow heart rate in the newborn. Talk to your doctor about the risks and benefits.
There isn't enough information about using tasimelteon during pregnancy to know if it's safe. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if tasimelteon passes into breast milk, so discuss breastfeeding with your doctor.
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How to Read This metoprolol vs tasimelteon Comparison
metoprolol is classified in the Beta-Blocker drug class, while tasimelteon sits within the Melatonin Receptor Agonist class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, metoprolol has 68,826 submissions while tasimelteon has 2,199. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to this heart medicine can lower the amount of natural sleep chemicals your body produces. this may stop the sleep medicine from working as well as it should.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for metoprolol or tasimelteon.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.