What the FDA labels say about taking them together
Ranolazine and simvastatin
Ranolazine's FDA label of January 23, 2026 names simvastatin in its drug interactions section, and simvastatin's label names ranolazine too. The simvastatin label: “The risk of myopathy and rhabdomyolysis is increased by concomitant use of amiodarone, dronedarone, ranolazine, or calcium channel blockers with ZOCOR.”
Check it at the source: the ranolazine FDA label on DailyMed (effective January 23, 2026, Glenmark Pharmaceuticals Inc., USA); the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC).
What does the ranolazine label say about simvastatin?
Ranolazine label, drug interactionsCYP3A substrates: Limit simvastatin to 20 mg when used with ranolazine.
Aspruzyo Sprinkle label (SUN PHARMACEUTICAL INDUSTRIES, INC., January 29, 2025), drug interactionsTitrate ASPRUZYO Sprinkle based on clinical response. (7.1) CYP3A substrates: Limit simvastatin to 20 mg when used with ASPRUZYO Sprinkle.
Source: FDA drug label (Aspruzyo Sprinkle, NDA216018), SUN PHARMACEUTICAL INDUSTRIES, INC., effective January 29, 2025 (SPL set dd9f81e4-50da-4551-aed5-559d304df42e), via openFDA
Source: FDA drug label (Ranolazine), Glenmark Pharmaceuticals Inc., USA, effective January 23, 2026 (SPL set 0cf58732-c242-49b0-8e3f-248778b4458d), via openFDA; the full label on DailyMed
What does the simvastatin label say about ranolazine?
Simvastatin label, drug interactionsAmiodarone, Dronedarone, Ranolazine, or Calcium Channel Blockers Clinical Impact: The risk of myopathy and rhabdomyolysis is increased by concomitant use of amiodarone, dronedarone, ranolazine, or calcium channel blockers with ZOCOR. Intervention: For patients taking verapamil, diltiazem, or dronedarone, do not exceed ZOCOR 10 mg daily. For patients taking amiodarone, amlodipine, or ranolazine, do not exceed ZOCOR 20 mg daily [see ].
Simvastatin label, warnings and precautionsZOCOR dosage modifications are recommended for patients taking lomitapide, verapamil, diltiazem, dronedarone, amiodarone, amlodipine or ranolazine [see Dosage and Administration (2.5) ].
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ranolazine | Simvastatin | |
|---|---|---|
| Labeled for | Angina | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.165 per tablet 500 mg tablet | $0.0321 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once