Simvastatin and Ranolazine Interaction
Drug interaction information between Simvastatin and Ranolazine.
Simvastatin and Ranolazine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Simvastatin and Ranolazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ranolazine increases the levels of simvastatin in your blood, which makes muscle pain or serious muscle damage more likely.
FDA Label Information
Amiodarone, Dronedarone, Ranolazine, or Calcium Channel Blockers Clinical Impact: The risk of myopathy and rhabdomyolysis is increased by concomitant use of amiodarone, dronedarone, ranolazine, or calcium channel blockers with ezetimibe and simvastatin. For patients taking amiodarone, amlodipine, or ranolazine, do not exceed ezetimibe and simvastatin 10 mg/20 mg daily [see Dosage and Administration ( 2.3 )].
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Ranolazine Also Interacts With
- Ketoconazole major
- Carbamazepine major
- Clarithromycin major
- Rifampin major
- Phenytoin major
Frequently Asked Questions
What SPL severity band is on file for Simvastatin + Ranolazine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Ranolazine's 31. In the major band specifically: Simvastatin has 11 (also Diltiazem, Verapamil, Cyclosporine, Amiodarone); Ranolazine has 12 (also Ketoconazole, Carbamazepine, Clarithromycin, Rifampin).
What mechanism field is on file for Simvastatin and Ranolazine?
Ranolazine increases the levels of simvastatin in your blood, which makes muscle pain or serious muscle damage more likely.
Ranolazine carries more major-labeled pairs than Simvastatin
SPL source-record counts only. This page's band is major · classes on file: Simvastatin (HMG-CoA Reductase Inhibitor (Statin)); Ranolazine (Late Sodium Current Inhibitor (Antianginal)).
Ranolazine has 12 major-labeled pairs vs Simvastatin's 11.
11 major · 9 moderate · 21 minor · 41 total
- Other major peers for Simvastatin
- Diltiazem
- Verapamil
- Cyclosporine
- Amiodarone
12 major · 7 moderate · 12 minor · 31 total
- Other major peers for Ranolazine
- Ketoconazole
- Carbamazepine
- Clarithromycin
- Rifampin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.