Rosiglitazone · more major-labeled pairs than Leflunomide
SPL labels Rosiglitazone + Leflunomide as minor; Rosiglitazone 11 / Leflunomide 20 in that band.
Mechanism on file: Leflunomide blocks the liver enzyme responsible for breaking down rosiglitazone. This results in higher amounts of rosiglitazone staying in your system.
FDA SPL severity: Minor
Rosiglitazone + Leflunomide · SPL mechanism field
Leflunomide blocks the liver enzyme responsible for breaking down rosiglitazone. This results in higher amounts of rosiglitazone staying in your system.
Minor band excerpt · Rosiglitazone with Leflunomide
In patients taking leflunomide, exposure of drugs metabolized by CYP2C8 (e.g., paclitaxel, pioglitazone, repaglinide, rosiglitazone) may be increased.
Rosiglitazone · 1 major-labeled pairs (vs Leflunomide's 0)
- Amiloride minor
- Cimetidine minor
- Digoxin minor
- Gemfibrozil minor
Leflunomide · 20 SPL pairs (broader portfolio than Rosiglitazone)
- Alosetron minor
- Atorvastatin minor
- Cimetidine minor
- Ciprofloxacin minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.