Gemfibrozil · more major-labeled pairs than Rosiglitazone
SPL labels Rosiglitazone + Gemfibrozil as minor; Rosiglitazone 11 / Gemfibrozil 8 in that band.
Mechanism on file: Gemfibrozil blocks a specific liver protein that normally breaks down rosiglitazone. This can cause the levels of rosiglitazone in your blood to rise.
FDA SPL severity: Minor
Rosiglitazone + Gemfibrozil · SPL mechanism field
Gemfibrozil blocks a specific liver protein that normally breaks down rosiglitazone. This can cause the levels of rosiglitazone in your blood to rise.
Minor band excerpt · Rosiglitazone with Gemfibrozil
7 DRUG INTERACTIONS Inhibitors of CYP2C8 (e.g., gemfibrozil) may increase rosiglitazone levels. (7.2) 7.1 Drugs Metabolized by Cytochrome P450 An inhibitor of CYP2C8 (e.g., gemfibrozil) may increase the AUC of rosiglitazone and an inducer of CYP2C8 (e.g., rifampin) may decrease the AUC of rosiglitazone.
Rosiglitazone · 11 minor + 12 total pairs
- Amiloride minor
- Cimetidine minor
- Digoxin minor
- Leflunomide minor
Gemfibrozil · 4 major-labeled pairs (vs Rosiglitazone's 1)
- Colchicine minor
- Colestipol minor
- Enzalutamide minor
- Metformin/Pioglitazone minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.