What the FDA labels say about taking them together
Ciprofloxacin and leflunomide
Leflunomide's FDA label of June 4, 2025 names ciprofloxacin in its drug interactions section; the ciprofloxacin labels PlainMeds reads (3) do not name leflunomide. The leflunomide label: “In patients taking ARAVA, exposure of drugs which are OAT3 substrates may be increased.”
Check it at the source: the ciprofloxacin FDA label on DailyMed (effective March 2, 2026, Bayer HealthCare Pharmaceuticals Inc.); the leflunomide FDA label on DailyMed (effective June 4, 2025, sanofi-aventis U.S. LLC).
What does the ciprofloxacin label say about leflunomide?
Ciprofloxacin's label (effective March 2, 2026) and its 2 other brand-application labels do not name leflunomide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cipro), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 888dc7f9-ad9c-4c00-8d50-8ddfd9bd27c0), via openFDA; the full label on DailyMed
What does the leflunomide label say about ciprofloxacin?
Leflunomide label, drug interactionsIn patients taking ARAVA, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased.
Source: FDA drug label (Arava), sanofi-aventis U.S. LLC, effective June 4, 2025 (SPL set 320f63f2-fac3-4aee-aff8-85724e00ef52), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ciprofloxacin | Leflunomide | |
|---|---|---|
| Labeled for | Diarrhea, Urinary tract infections, Bacterial infections | Rheumatoid arthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.123 per tablet 500 mg tablet | $0.324 per tablet 10 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once