Leflunomide and Atorvastatin Interaction
Drug interaction information between Leflunomide and Atorvastatin.
Leflunomide and Atorvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Leflunomide and Atorvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Leflunomide can interfere with how your body moves and clears atorvastatin, potentially leading to higher levels of the drug in your blood.
FDA Label Information
For other substrates of BCRP (e.g., mitoxantrone) and drugs in the OATP family (e.g., methotrexate, rifampin), especially HMG-Co reductase inhibitors (e.g., atorvastatin, nateglinide, pravastatin, repaglinide, and simvastatin), consider reducing the dose of these drugs and monitor patients closely for signs and symptoms of increased exposures to the drugs while patients are taking leflunomide [see Clinical Pharmacology (12.3) ].
Leflunomide Also Interacts With
- Rosuvastatin minor
- Simvastatin minor
- Furosemide minor
- Duloxetine minor
- Pravastatin minor
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Leflunomide + Atorvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Atorvastatin has 36 labeled pairs on file vs Leflunomide's 20. In the minor band specifically: Leflunomide has 20 (also Rosuvastatin, Simvastatin, Furosemide, Duloxetine); Atorvastatin has 25 (also Estradiol, Norethindrone, Ketoconazole, Erythromycin).
What mechanism field is on file for Leflunomide and Atorvastatin?
Leflunomide can interfere with how your body moves and clears atorvastatin, potentially leading to higher levels of the drug in your blood.
Atorvastatin carries more major-labeled pairs than Leflunomide
SPL source-record counts only. This page's band is minor · classes on file: Leflunomide (Disease-Modifying Antirheumatic Drug (DMARD)); Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Atorvastatin has 3 major-labeled pairs vs Leflunomide's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 20 minor · 20 total
- Other minor peers for Leflunomide
- Rosuvastatin
- Simvastatin
- Furosemide
- Duloxetine
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Estradiol
- Norethindrone
- Ketoconazole
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.