Cimetidine · more major-labeled pairs than Rosiglitazone
SPL labels Rosiglitazone + Cimetidine as minor; Rosiglitazone 11 / Cimetidine 63 in that band.
Mechanism on file: Cimetidine can interfere with how the body removes the other medication through the kidneys. This happens because both drugs use the same pathway to leave the body.
FDA SPL severity: Minor
Rosiglitazone + Cimetidine · SPL mechanism field
Cimetidine can interfere with how the body removes the other medication through the kidneys. This happens because both drugs use the same pathway to leave the body.
Minor band excerpt · Rosiglitazone with Cimetidine
[See Clinical Pharmacology (12.4).] 7.2 Cationic Drugs Although drug interactions for metformin with cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, and vancomycin) remain theoretical (except for cimetidine), careful patient monitoring and dose adjustment of AVANDAMET and/or the interfering drug is recommended in patients who are taking cationic medications that are excreted via the proximal renal tubular secretory system.
Rosiglitazone · 11 minor + 12 total pairs
- Amiloride minor
- Digoxin minor
- Gemfibrozil minor
- Leflunomide minor
Cimetidine · 4 major-labeled pairs (vs Rosiglitazone's 1)
- Albendazole minor
- Alogliptin minor
- Alosetron minor
- Alprazolam minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.