Cimetidine · more major-labeled pairs than Leflunomide
SPL labels Leflunomide + Cimetidine as minor; Leflunomide 20 / Cimetidine 63 in that band.
Mechanism on file: Leflunomide blocks a transport system that normally helps remove cimetidine from your body. This causes cimetidine levels in your blood to increase.
FDA SPL severity: Minor
Leflunomide + Cimetidine · SPL mechanism field
Leflunomide blocks a transport system that normally helps remove cimetidine from your body. This causes cimetidine levels in your blood to increase.
Minor band excerpt · Leflunomide with Cimetidine
In patients taking leflunomide, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased.
Leflunomide · 20 minor + 20 total pairs
- Alosetron minor
- Atorvastatin minor
- Ciprofloxacin minor
- Duloxetine minor
Cimetidine · 4 major-labeled pairs (vs Leflunomide's 0)
- Albendazole minor
- Alogliptin minor
- Alosetron minor
- Alprazolam minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.