Rolapitant and Rosuvastatin Interaction
Drug interaction information between Rolapitant and Rosuvastatin.
Rolapitant and Rosuvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rolapitant and Rosuvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rolapitant blocks a protein that helps clear rosuvastatin from your body, which can lead to higher levels of the statin in your blood.
FDA Label Information
Use the lowest effective dose of rosuvastatin (see prescribing information for additional information on recommended dosing).
Rolapitant Also Interacts With
- Pimozide major
- Thioridazine major
- Rifampin moderate
- Warfarin minor
- Methotrexate minor
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Frequently Asked Questions
What SPL severity band is on file for Rolapitant + Rosuvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rosuvastatin has 21 labeled pairs on file vs Rolapitant's 9. In the minor band specifically: Rolapitant has 6 (also Warfarin, Methotrexate, Digoxin, Dextromethorphan); Rosuvastatin has 10 (also Fenofibrate, Warfarin, Brexpiprazole, Darunavir).
What mechanism field is on file for Rolapitant and Rosuvastatin?
Rolapitant blocks a protein that helps clear rosuvastatin from your body, which can lead to higher levels of the statin in your blood.
Rosuvastatin carries more major-labeled pairs than Rolapitant
SPL source-record counts only. This page's band is minor · classes on file: Rolapitant (NK1 Receptor Antagonist (Antiemetic)); Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Rosuvastatin has 3 major-labeled pairs vs Rolapitant's 2. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 6 minor · 9 total
- Other minor peers for Rolapitant
- Warfarin
- Methotrexate
- Digoxin
- Dextromethorphan
3 major · 8 moderate · 10 minor · 21 total
- Other minor peers for Rosuvastatin
- Fenofibrate
- Warfarin
- Brexpiprazole
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.