Rolapitant and Rifampin Interaction
Drug interaction information between Rolapitant and Rifampin.
Rolapitant and Rifampin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rolapitant and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin significantly lowers the levels of rolapitant in your blood. This makes the medication much less effective at preventing nausea and vomiting.
FDA Label Information
rifampin) Clinical Impact: Co-administration of VARUBI with rifampin can significantly reduce the plasma concentrations of rolapitant and decrease the efficacy of VARUBI [see Clinical Pharmacology (12.3) ] . Strong CYP3A4 Inducers (e.g., rifampin) : significantly reduced plasma concentrations of rolapitant can decrease the efficacy of VARUBI; avoid use of VARUBI in patients who require chronic administration of such drugs.
Rolapitant Also Interacts With
- Pimozide major
- Thioridazine major
- Rosuvastatin minor
- Warfarin minor
- Methotrexate minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Rolapitant + Rifampin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Rolapitant's 9. In the moderate band specifically: Rolapitant has 1; Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban).
What mechanism field is on file for Rolapitant and Rifampin?
Rifampin significantly lowers the levels of rolapitant in your blood. This makes the medication much less effective at preventing nausea and vomiting.
Rifampin carries more major-labeled pairs than Rolapitant
SPL source-record counts only. This page's band is moderate · classes on file: Rolapitant (NK1 Receptor Antagonist (Antiemetic)); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Rolapitant's 2. This page itself is in the moderate band, not the major band.
2 major · 1 moderate · 6 minor · 9 total
Rolapitant has no other moderate-band peer in this dataset besides Rifampin.
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.