Rolapitant and Pimozide Interaction
Drug interaction information between Rolapitant and Pimozide.
Rolapitant and Pimozide have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Rolapitant and Pimozide. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Rolapitant blocks the body from breaking down pimozide, which can lead to dangerously high levels of the drug in the blood. This buildup can cause serious or life-threatening heart rhythm problems.
What To Do
Do not take these two medications together. Your doctor should use a different medicine for your nausea or your heart condition.
Rolapitant Also Interacts With
- Thioridazine major
- Rifampin moderate
- Rosuvastatin minor
- Warfarin minor
- Methotrexate minor
Pimozide Also Interacts With
- Aprepitant major
- Citalopram major
- Clarithromycin major
- Darunavir major
- Escitalopram major
Frequently Asked Questions
Can I take Rolapitant and Pimozide together?
This is a major interaction. Do not take these two medications together. Your doctor should use a different medicine for your nausea or your heart condition.
How serious is the interaction between Rolapitant and Pimozide?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Rolapitant and Pimozide interact?
Rolapitant blocks the body from breaking down pimozide, which can lead to dangerously high levels of the drug in the blood. This buildup can cause serious or life-threatening heart rhythm problems.
Understanding the Rolapitant and Pimozide Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Rolapitant belongs to the NK1 Receptor Antagonist (Antiemetic) class and Pimozide belongs to the Typical Antipsychotic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Rolapitant blocks the body from breaking down pimozide, which can lead to dangerously high levels of the drug in the blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Rolapitant has 9 total documented interactions on file in this dataset, and Pimozide has 24. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Do not take these two medications together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Rolapitant or Pimozide based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.