Rolapitant and Pimozide Interaction
Drug interaction information between Rolapitant and Pimozide.
Rolapitant and Pimozide have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Rolapitant and Pimozide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rolapitant blocks the body from breaking down pimozide, which can lead to dangerously high levels of the drug in the blood. This buildup can cause serious or life-threatening heart rhythm problems.
Rolapitant Also Interacts With
- Thioridazine major
- Rifampin moderate
- Rosuvastatin minor
- Warfarin minor
- Methotrexate minor
Pimozide Also Interacts With
- Aprepitant major
- Citalopram major
- Clarithromycin major
- Darunavir major
- Escitalopram major
Frequently Asked Questions
What SPL severity band is on file for Rolapitant + Pimozide?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pimozide has 24 labeled pairs on file vs Rolapitant's 9. In the major band specifically: Rolapitant has 2 (also Thioridazine); Pimozide has 12 (also Aprepitant, Citalopram, Clarithromycin, Darunavir).
What mechanism field is on file for Rolapitant and Pimozide?
Rolapitant blocks the body from breaking down pimozide, which can lead to dangerously high levels of the drug in the blood. This buildup can cause serious or life-threatening heart rhythm problems.
Pimozide carries more major-labeled pairs than Rolapitant
SPL source-record counts only. This page's band is major · classes on file: Rolapitant (NK1 Receptor Antagonist (Antiemetic)); Pimozide (Typical Antipsychotic).
Pimozide has 12 major-labeled pairs vs Rolapitant's 2.
12 major · 0 moderate · 12 minor · 24 total
- Other major peers for Pimozide
- Aprepitant
- Citalopram
- Clarithromycin
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.