Rolapitant and Thioridazine Interaction
Drug interaction information between Rolapitant and Thioridazine.
Rolapitant and Thioridazine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Rolapitant and Thioridazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rolapitant prevents the body from processing thioridazine, causing it to build up to unsafe levels. High levels of this drug can cause life-threatening heart rhythm issues.
Rolapitant Also Interacts With
- Pimozide major
- Rifampin moderate
- Rosuvastatin minor
- Warfarin minor
- Methotrexate minor
Thioridazine Also Interacts With
- Fluoxetine major
- Paroxetine major
- Abiraterone moderate
- Darifenacin moderate
- Tetrabenazine moderate
Frequently Asked Questions
What SPL severity band is on file for Rolapitant + Thioridazine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Thioridazine has 17 labeled pairs on file vs Rolapitant's 9. In the major band specifically: Rolapitant has 2 (also Pimozide); Thioridazine has 3 (also Fluoxetine, Paroxetine).
What mechanism field is on file for Rolapitant and Thioridazine?
Rolapitant prevents the body from processing thioridazine, causing it to build up to unsafe levels. High levels of this drug can cause life-threatening heart rhythm issues.
Thioridazine carries more major-labeled pairs than Rolapitant
SPL source-record counts only. This page's band is major · classes on file: Rolapitant (NK1 Receptor Antagonist (Antiemetic)); Thioridazine (Typical Antipsychotic (Phenothiazine)).
Thioridazine has 3 major-labeled pairs vs Rolapitant's 2.
3 major · 3 moderate · 11 minor · 17 total
- Other major peers for Thioridazine
- Fluoxetine
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.