What the FDA labels say about taking them together
Rolapitant and thioridazine
Rolapitant's FDA label of August 19, 2020 names thioridazine in its contraindications section; the thioridazine label PlainMeds reads does not name rolapitant. The rolapitant label: “Increased plasma concentrations of thioridazine and pimozide are associated with serious and/or life-threatening events of QT prolongation and Torsades de Pointes.”
Check it at the source: the rolapitant FDA label on DailyMed (effective August 19, 2020, TerSera Therapeutics LLC); the thioridazine FDA label on DailyMed (effective November 11, 2025, Mylan Institutional Inc.).
What does the rolapitant label say about thioridazine?
Rolapitant label, contraindicationsCONTRAINDICATIONS VARUBI is contraindicated in patients taking CYP2D6 substrates with a narrow therapeutic index, such as thioridazine and pimozide.
Rolapitant label, drug interactionsNarrow Therapeutic Index Drugs (Thioridazine and Pimozide) Clinical Impact: Increased plasma concentrations of thioridazine and pimozide are associated with serious and/or life-threatening events of QT prolongation and Torsades de Pointes. Intervention: VARUBI is contraindicated in patients taking CYP2D6 substrates with a narrow therapeutic index such as thioridazine and pimozide. If patients require these drugs, use an alternative antiemetic to VARUBI or an alternative to thioridazine or pimozide that is not metabolized by CYP2D6 [see, ].
Rolapitant label, warnings and precautionsBefore starting VARUBI, consider if patients require: thioridazine or pimozide; if so, use an alternative antiemetic to VARUBI or an alternative to thioridazine or pimozide that is not metabolized by CYP2D6. other CYP2D6 substrates; if so, consult the prescribing information for the CYP2D6 substrate for additional information about interactions with CYP2D6 inhibitors.
Source: FDA drug label (Varubi), TerSera Therapeutics LLC, effective August 19, 2020 (SPL set a52896cd-4a98-49b8-82db-bf1985a64d97), via openFDA; the full label on DailyMed
What does the thioridazine label say about rolapitant?
Thioridazine's label (effective November 11, 2025) does not name rolapitant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Thioridazine Hydrochloride), Mylan Institutional Inc., effective November 11, 2025 (SPL set 52fea941-0b47-41c1-b00d-f88150e8ab93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Rolapitant | Thioridazine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.571 per tablet 25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once