Rolapitant and Warfarin Interaction
Drug interaction information between Rolapitant and Warfarin.
Rolapitant and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rolapitant and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
It is not clear exactly how these drugs interact, but taking them together might change how well your blood thins.
FDA Label Information
Warfarin Clinical Impact: Although co-administration of intravenous rolapitant (VARBI is not approved for intravenous use), which has a higher C max than oral VARUBI, with warfarin did not substantially increase the systemic exposure to S-warfarin, the active enantiomer, the effects on INR and prothrombin time were not studied [see Clinical Pharmacology (12.3) ] . Intervention: Monitor INR and prothrombin time and adjust the dosage of warfarin, as needed with concomitant use of VARUBI, to maintain the target INR range. ( 7 ) Warfarin : Monitor for increased INR or prothrombin time; adjust...
Rolapitant Also Interacts With
- Pimozide major
- Thioridazine major
- Rifampin moderate
- Rosuvastatin minor
- Methotrexate minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Rolapitant + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Rolapitant's 9. In the minor band specifically: Rolapitant has 6 (also Rosuvastatin, Methotrexate, Digoxin, Dextromethorphan); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Rolapitant and Warfarin?
It is not clear exactly how these drugs interact, but taking them together might change how well your blood thins.
Warfarin's labeled portfolio outnumbers Rolapitant
SPL source-record counts only. This page's band is minor · classes on file: Rolapitant (NK1 Receptor Antagonist (Antiemetic)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
2 major · 1 moderate · 6 minor · 9 total
- Other minor peers for Rolapitant
- Rosuvastatin
- Methotrexate
- Digoxin
- Dextromethorphan
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.